SCHEMBL4095805

SCHEMBL4095805

Cc1cc(C(=O)CCc2sc(-c3ccc(C(F)(F)F)cc3)cc2C)ccc1O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.38
HSD17B1 P14061 3/20 0.38
HSD17B2 P37059 3/20 0.38
ESRRG P62508 1/20 0.37
MAPT P10636 3/20 0.36
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
HSP90AA1 P07900 1/20 0.36
CRHBP P24387 1/20 0.36
KMT2A Q03164 1/20 0.36
CRHR2 Q13324 1/20 0.36
MMP1 P03956 1/20 0.36
MAPK11 Q15759 1/20 0.36
MAPK14 Q16539 1/20 0.36
FFAR1 O14842 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36
FRK P42685 1/20 0.36
CAMK2B Q13554 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4097006 0.89 HSD17B1 (0.35) CCR1HSD17B1HSD17B2ESRRGMAPT
SCHEMBL4103423 0.83 PPARD (0.54) PPARGPPARDPPARA
SCHEMBL4099232 0.82 PPARA (0.51) PPARGPPARDPPARA
SCHEMBL5655928 0.82 MAPT (0.56) MAPTFFAR1NPC1ALDH1A1GAA
SCHEMBL27602733 0.81 PPARG (0.45) CCR1HSD17B1HSD17B2MAPTKDM4E
SCHEMBL4106067 0.80 PPARD (0.41) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL1673291 0.79 PPARD (0.49) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL4514638 0.79 MAPT (0.46) MAPTKDM4EMEN1HSP90AA1CRHBP
SCHEMBL1034982 0.77 BCL2L1 (0.37) ESRRGMEN1KMT2AMMP1BCL2L1
SCHEMBL1032891 0.77 BCL2L1 (0.37) ESRRGMAPTMEN1KMT2AMMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta NIPPON CHEMIPHAR CO., LTD. (JP) 2009-09-24 US disclosed
EP-1854784-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2007-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta PPARG, PPARA, PPARD CCR1 1067/4885HSD17B1 140/4885HSD17B2 192/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.