Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.82 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.82 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.82 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.82 |
| ▸ | USP2 | O75604 | 3/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.67 |
| ▸ | CDK9 | P50750 | 4/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | BACE1 | P56817 | 5/20 | 0.57 |
| ▸ | ABL1 | P00519 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4109231 | 0.88 | CCNT1 (0.77) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL4096722 | 0.87 | CYP1A2 (0.76) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL4108631 | 0.84 | BACE1 (0.81) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL8516577 | 0.83 | CYP1A2 (0.86) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL8513621 | 0.81 | CYP1A2 (0.74) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL17022942 | 0.81 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL4101898 | 0.80 | CCNT1 (1.00) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL6532132 | 0.79 | CYP1A2 (0.67) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL8515965 | 0.79 | CYP1A2 (0.70) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 | |
| SCHEMBL8515866 | 0.79 | CYP3A4 (0.70) | CYP1A2CYP3A4CYP2C19CYP2C9CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678147-B1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | LEAD DISCOVERY CENTER GMBH (DE) | 2012-08-08 | — | — | EP | claimed |
| US-20090221581-A1 | Methods of treating pain | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | US | claimed |
| EP-1678147-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC Biotech AG (DE) | 2006-07-12 | — | — | EP | claimed |
| WO-2005026129-A1 | PHARMACEUTICALLY ACTIVE 4,6-DISUBSTITUTED AMINOPYRIMIDINE DERIVATIVES AS MODULATORS OF PROTEIN KINASES | GPC BIOTECH AG (DE) | 2005-03-24 | — | — | WO | claimed |
| US-20090221581-A1 | Methods of treating pain | ASTRAZENECA AB (SE) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221581-A1 | Methods of treating pain | CDK5, CAMKK2, CDK3 | CYP1A2 4521/4885CYP3A4 4829/4885CYP2C19 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.