Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.71 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.71 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.71 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.71 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.71 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.71 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.71 |
| ▸ | PRKACA | P17612 | 2/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.71 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.71 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.71 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.71 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.71 |
| ▸ | PRKCG | P05129 | 1/20 | 0.71 |
| ▸ | LCK | P06239 | 1/20 | 0.71 |
| ▸ | LYN | P07948 | 1/20 | 0.71 |
| ▸ | RET | P07949 | 1/20 | 0.71 |
| ▸ | PIM1 | P11309 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.71 |
| ▸ | FLT4 | P35916 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640842 | 0.85 | MAPK14 (0.80) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| Sb-220025 SCHEMBL173441 | 0.83 | MAPK14 (1.00) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| Sb-220025 SCHEMBL18066291 | 0.82 | MAPK14 (0.98) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL7720179 | 0.79 | MAPK14 (0.69) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL7688265 | 0.79 | MAPK14 (0.45) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL7767922 | 0.78 | MAPK14 (0.63) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL1906575 | 0.77 | MAPK14 (0.88) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL4323452 | 0.77 | MAPK14 (0.70) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL20550753 | 0.75 | MAPK14 (0.91) | MAPK14CSNK1DMAPK11MAPK13MAPK12 | |
| SCHEMBL7715290 | 0.75 | MAPK14 (0.56) | MAPK14CSNK1DMAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8986696-B2 | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints | DEPUY MITEK, INC. (US) | 2015-03-24 | — | — | US | disclosed |
| US-20090162376-A1 | Trans-capsular administration of p38 map kinase inhibitors into orthopedic joints | DEPUY MITEK, LLC | 2009-06-25 | — | — | US | disclosed |
| US-20090162351-A1 | Transdiscal administration of inhibitors of p38 MAP kinase | DEPUY SPINE, INC. (US) | 2009-06-25 | — | — | US | disclosed |