Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.45 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.45 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PRKCG | P05129 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | LYN | P07948 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.45 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6907211 | 0.87 | MAPK14 (0.61) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL7688263 | 0.84 | MAPK14 (0.42) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL4098093 | 0.79 | MAPK14 (0.71) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL7058352 | 0.75 | MAPK14 (0.60) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL7720179 | 0.73 | MAPK14 (0.69) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL6907208 | 0.70 | MAPK14 (0.57) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL7722180 | 0.69 | MAPK14 (0.53) | MAPK14MAPK11MAPK13MAPK12BRD4 | |
| SCHEMBL13819564 | 0.65 | MAPK14 (0.74) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL7058351 | 0.64 | MAPK14 (0.55) | MAPK14MAPK11MAPK13MAPK12RIPK2 | |
| SCHEMBL1640842 | 0.64 | MAPK14 (0.80) | MAPK14MAPK11MAPK13MAPK12RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6335340-B1 | REACTING POLYMER BOUND 2-THIOPYRIMIDINE-4-YL IMINE WITH AN ISONITRILE; OXIDATION TO SULFONE OR SULFOXIDE TO RELEASE; AMINATION; ADMINISTERING AS CYTOKINE, INTERLEUKIN, AND TUMOR NECROSIS INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2002-01-01 | — | — | US | disclosed |