Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 5/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4114277 | 1.00 | RIPK1 (0.41) | RIPK1SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL3991385 | 1.00 | RIPK1 (0.41) | RIPK1SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL17104487 | 0.89 | RIPK1 (0.43) | RIPK1SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL4114777 | 0.87 | ALDH1A1 (0.37) | SLC6A4SLC6A3HRH3KDM1A | |
| SCHEMBL3987952 | 0.87 | ALDH1A1 (0.37) | SLC6A4SLC6A3HRH3KDM1A | |
| SCHEMBL3993930 | 0.87 | ALDH1A1 (0.37) | SLC6A4SLC6A3HRH3KDM1A | |
| SCHEMBL2242113 | 0.85 | RIPK1 (0.48) | RIPK1SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL2331703 | 0.84 | KDM4E (0.45) | RIPK1SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL5805602 | 0.81 | KDM1A (0.39) | RIPK1SLC6A2SLC6A4SLC6A3HRH3 | |
| SCHEMBL18226601 | 0.76 | KDM1A (0.40) | SLC6A2SLC6A4SLC6A3KDM1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670476-A4 | PHENYL PYRROLIDINE ETHER TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2009-05-27 | — | — | EP | disclosed |
| US-7468437-B2 | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2008-12-23 | — | — | US | disclosed |
| US-20070043015-A1 | Phenyl pyrrolidine ether tachykinin receptor antagonists | MERCK & CO., INC. (US) | 2007-02-22 | — | — | US | disclosed |
| EP-1670476-A2 | PHENYL PYRROLIDINE ETHER TACHYKININ RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2006-06-21 | — | — | EP | disclosed |
| WO-2005032464-A2 | PHENYL PYRROLIDINE ETHER TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070043015-A1 | Phenyl pyrrolidine ether tachykinin receptor antagonists | TACR1, NPSR1, TACR2 | RIPK1 1789/4885SLC6A2 707/4885SLC6A4 384/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.