SCHEMBL409971

SCHEMBL409971

OC(CNc1ccncc1)Cn1c2ccc(Br)cc2c2cc(Br)ccc21

nearest known ligand 0.77

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
DNM1 Q05193 9/20 0.77
MAPT P10636 5/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
HTT P42858 3/20 0.52
NPSR1 Q6W5P4 3/20 0.52
KMT2A Q03164 2/20 0.52
LMNA P02545 2/20 0.50
TP53 P04637 2/20 0.50
MAPK1 P28482 2/20 0.50
ALDH1A1 P00352 2/20 0.50
P2RX3 P56373 1/20 0.50
BAX Q07812 1/20 0.49
CYP3A4 P08684 1/20 0.48
ALOX15 P16050 1/20 0.48
MEN1 O00255 1/20 0.46
RAD52 P43351 1/20 0.46
TSPO P30536 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL410692 0.89 DNM1 (0.85) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL29351340 0.87 DNM1 (1.00) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL410147 0.87 DNM1 (1.00) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL29391692 0.87 DNM1 (1.00) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL410497 0.85 DNM1 (0.74) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL18721925 0.85 DNM1 (0.77) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL16923756 0.85 DNM1 (0.55) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL408405 0.85 DNM1 (0.77) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL410581 0.85 DNM1 (0.77) DNM1MAPTSMN1; SMN2HTTNPSR1
SCHEMBL18925966 0.82 DNM1 (0.73) DNM1MAPTSMN1; SMN2HTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 186 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10183011-B2 Anti-depression compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-01-22 US claimed
US-10172827-B2 Pro-neurogenic compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2019-01-08 US claimed
US-20180318255-A1 Pro-Neurogenic Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2018-11-08 US claimed
EP-2385829-B1 PRO-NEUROGENIC COMPOUNDS UNIV TEXAS (US) 2018-08-01 EP claimed
US-9962368-B2 Pro-neurogenic compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2018-05-08 US claimed
EP-2590647-B1 PRO-NEUROGENIC COMPOUNDS UNIV TEXAS (US) 2017-11-08 EP claimed
US-20170157092-A1 Anti-depression Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2017-06-08 US claimed
US-9616048-B2 Anti-depression compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2017-04-11 US claimed
US-20160362372-A1 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2016-12-15 US claimed
US-20160206596-A1 Anti-depression Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2016-07-21 US claimed
EP-2590647-A2 PRO-NEUROGENIC COMPOUNDS Board of Regents of the University of Texas System (US) 2013-05-15 EP claimed
US-20130040977-A1 Pro-Neurogenic Compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM 2013-02-14 US claimed
US-8362277-B2 Pro-neurogenic compounds BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2013-01-29 US claimed
US-20120022096-A1 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-01-26 US claimed
WO-2012006419-A2 PRO-NEUROGENIC COMPOUNDS BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) 2012-01-12 WO claimed
EP-2385829-A1 PRO-NEUROGENIC COMPOUNDS Board of Regents of the University of Texas System (US) 2011-11-16 EP claimed
US-8039041-B2 Electroluminescent devices with electrode protection CAMBRIDGE DISPLAY TECHNOLOGY, LTD. (GB) 2011-10-18 US claimed
US-20110015217-A1 Pro-Neurogenic Compounds BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2011-01-20 US claimed
US-20110003836-A1 Pro-Neurogenic Compounds BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM 2011-01-06 US claimed
WO-2010081115-A1 PRO-NEUROGENIC COMPOUNDS UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER (US) 2010-07-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120022096-A1 PRO-NEUROGENIC COMPOUNDS BDNF, GAP43, DCX DNM1 897/4885MAPT 136/4885SMN1; SMN2 50/4885
US-10172827-B2 Pro-neurogenic compounds DCX, GAP43, BDNF DNM1 510/4885MAPT 559/4885SMN1; SMN2 182/4885
US-20180318255-A1 Pro-Neurogenic Compounds BDNF, GAP43, DCX DNM1 897/4885MAPT 136/4885SMN1; SMN2 50/4885
US-20110015217-A1 Pro-Neurogenic Compounds DCX, GAP43, BDNF DNM1 510/4885MAPT 559/4885SMN1; SMN2 182/4885
US-10183011-B2 Anti-depression compounds BDNF, DCX, GAP43 DNM1 638/4885MAPT 142/4885SMN1; SMN2 63/4885
US-20130040977-A1 Pro-Neurogenic Compounds BDNF, GAP43, DCX DNM1 897/4885MAPT 136/4885SMN1; SMN2 50/4885
US-20110003836-A1 Pro-Neurogenic Compounds DCX, GAP43, BDNF DNM1 538/4885MAPT 571/4885SMN1; SMN2 161/4885
US-20160362372-A1 PRO-NEUROGENIC COMPOUNDS DCX, GAP43, BDNF DNM1 510/4885MAPT 559/4885SMN1; SMN2 182/4885
US-20160206596-A1 Anti-depression Compounds BDNF, DCX, GAP43 DNM1 638/4885MAPT 142/4885SMN1; SMN2 63/4885
US-20170157092-A1 Anti-depression Compounds BDNF, DCX, GAP43 DNM1 638/4885MAPT 142/4885SMN1; SMN2 63/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.