Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.74 |
| ▸ | KDR | P35968 | 8/20 | 0.74 |
| ▸ | INSR | P06213 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PDE6D | O43924 | 1/20 | 0.41 |
| ▸ | PDE6A | P16499 | 1/20 | 0.41 |
| ▸ | PDE6G | P18545 | 1/20 | 0.41 |
| ▸ | PDE6B | P35913 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3980174 | 0.83 | IGF1R (0.56) | IGF1RFGFR1KDRINSRKCNH2 | |
| SCHEMBL3982541 | 0.81 | IGF1R (0.77) | IGF1RFGFR1KDRINSRKCNH2 | |
| SCHEMBL4010896 | 0.81 | IGF1R (0.75) | IGF1RFGFR1KDRINSR | |
| SCHEMBL13844709 | 0.80 | FGFR1 (0.86) | IGF1RFGFR1KDRINSREGFR | |
| Hydrochloric Acid SCHEMBL4106603 | 0.79 | FGFR1 (0.85) | IGF1RFGFR1KDRINSREGFR | |
| SCHEMBL4006828 | 0.79 | IGF1R (0.47) | IGF1RFGFR1KDRINSREGFR | |
| SCHEMBL4100222 | 0.78 | IGF1R (0.48) | IGF1RFGFR1KDRKCNH2PDE6D | |
| SCHEMBL4014265 | 0.77 | IGF1R (0.70) | IGF1RFGFR1KDRINSR | |
| SCHEMBL3983403 | 0.76 | IGF1R (0.67) | IGF1RFGFR1KDRINSREGFR | |
| SCHEMBL5109468 | 0.73 | IGF1R (0.65) | IGF1RFGFR1KDRINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |