Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | PDE6D | O43924 | 1/20 | 0.40 |
| ▸ | PDE6A | P16499 | 1/20 | 0.40 |
| ▸ | PDE6G | P18545 | 1/20 | 0.40 |
| ▸ | PDE6B | P35913 | 1/20 | 0.40 |
| ▸ | PDE6C | P51160 | 1/20 | 0.40 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4092263 | 0.84 | KDM4E (0.41) | IGF1RFGFR1KDRADORA2AADORA1 | |
| SCHEMBL4099760 | 0.78 | IGF1R (0.74) | IGF1RFGFR1KDRPDE6DPDE6A | |
| SCHEMBL27773464 | 0.73 | IGF1R (0.47) | IGF1RFGFR1KDRMEN1KMT2A | |
| SCHEMBL18292338 | 0.68 | MAOA (0.60) | IGF1RFGFR1KDRVNN1PDE6D | |
| SCHEMBL3982541 | 0.67 | IGF1R (0.77) | IGF1RFGFR1KDRVNN1PDE6D | |
| SCHEMBL19406645 | 0.67 | VNN1 (0.53) | IGF1RFGFR1KDRVNN1ADORA2A | |
| SCHEMBL27997938 | 0.67 | PIK3CA (0.49) | IGF1RFGFR1VNN1ADORA2AADORA1 | |
| SCHEMBL4011600 | 0.66 | DYRK1A (0.43) | FGFR1KDRGAAMAPTALDH1A1 | |
| SCHEMBL4608258 | 0.62 | DHFR (0.46) | FGFR1ALDH1A1TSHRHSD17B10DHFR | |
| SCHEMBL3983403 | 0.62 | IGF1R (0.67) | IGF1RFGFR1KDRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056886-A1 | PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF FGFR ACTIVITY | ASTRAZENECA AB (SE) | 2009-05-07 | — | — | WO | disclosed |