SCHEMBL4100199

SCHEMBL4100199

Cc1cc(C(=O)CCc2cc(-c3ccc(C(F)(F)F)cc3)nn2C(C)C)ccc1OC(C)C(=O)O

nearest known ligand 0.45

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 14/20 0.45
PPARA Q07869 6/20 0.45
PTGDR2 Q9Y5Y4 3/20 0.39
ABCB11 O95342 1/20 0.38
TSHR P16473 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
HTR2B P41595 1/20 0.37
GCGR P47871 1/20 0.36
GIPR P48546 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4104227 0.92 PPARD (0.37) PPARDPPARAGCGRGIPR
SCHEMBL4105650 0.88 PPARD (0.51) PPARDPPARA
SCHEMBL1765886 0.87 PPARA (0.48) PPARDPPARA
SCHEMBL24742426 0.86 PPARD (0.38) PPARDPPARAGCGRGIPR
SCHEMBL12648301 0.86 PPARD (0.38) PPARDPPARAGCGRGIPR
SCHEMBL30003505 0.86 PPARD (0.38) PPARDPPARAGCGRGIPR
SCHEMBL4100294 0.84 PPARD (0.40) PPARDPPARAGCGR
SCHEMBL4101344 0.79 PPARA (0.47) PPARDPPARA
SCHEMBL12732561 0.79 HDAC3 (0.36) PPARDPPARAGCGR
SCHEMBL12732668 0.78 PPARA (0.44) PPARDPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta NIPPON CHEMIPHAR CO., LTD. (JP) 2009-09-24 US disclosed
EP-1854784-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2007-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta PPARG, PPARA, PPARD PPARD 3/4885PPARA 2/4885PTGDR2 204/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.