⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thiourea SCHEMBL9443171 | 0.79 | TSHR (0.40) | — | |
| SCHEMBL4974133 | 0.79 | — | — | |
| SCHEMBL1243651 | 0.74 | — | — | |
| SCHEMBL20668529 | 0.74 | — | — | |
| SCHEMBL7093108 | 0.74 | — | — | |
| SCHEMBL2141202 | 0.73 | — | — | |
| SCHEMBL8297109 | 0.72 | — | — | |
| SCHEMBL13366391 | 0.72 | — | — | |
| SCHEMBL276778 | 0.72 | — | — | |
| SCHEMBL5049546 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273716-B2 | Use of LHRH antagonists for intermittent treatments | SPECTRUM PHARMACEUTICALS, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-20090221569-A1 | USE OF LHRH ANTAGONISTS FOR INTERMITTENT TREATMENTS | AETERNA ZENTARIS GMBH (DE) | 2009-09-03 | — | — | US | disclosed |
| US-7375127-B2 | Tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | AE ZENTARIS GMBH (DE) | 2008-05-20 | — | — | US | disclosed |
| US-20060014818-A1 | Novel tetrahydrocarbazole derivatives having improved biological action and improved solubility as ligands of G-protein coupled receptors (GPCRs) | MUSC FOUNDATION FOR RESEARCH DEVELOPMENT | 2006-01-19 | — | — | US | disclosed |