Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TYMS | P04818 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4100989 | 0.87 | MAPT (0.40) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL4103751 | 0.81 | KDM4E (0.51) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL8855451 | 0.73 | KDM4E (0.51) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL8855594 | 0.72 | MAPT (0.50) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL8855455 | 0.71 | MAPT (0.51) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL8855590 | 0.70 | MAPT (0.50) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL8855624 | 0.68 | MAPT (0.52) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL8855581 | 0.67 | CHUK (0.41) | MAPTKDM4EHPGDPOLBSMN1; SMN2 | |
| SCHEMBL8855487 | 0.67 | MAPT (0.51) | MAPTKDM4EHPGDPOLBGAA | |
| SCHEMBL11186264 | 0.65 | MAPT (0.38) | MAPTKDM4EHPGDPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063240-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF AURORA KINASE | ARROW THERAPEUTICS LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |