Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8855451 | 0.85 | KDM4E (0.51) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL8855594 | 0.84 | MAPT (0.50) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL8855455 | 0.82 | MAPT (0.51) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL8855590 | 0.81 | MAPT (0.50) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL4100990 | 0.81 | MAPT (0.40) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL14819940 | 0.80 | GAA (0.51) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL4100989 | 0.78 | MAPT (0.40) | KDM4EMAPTHPGDPOLBGAA | |
| SCHEMBL7617288 | 0.75 | SMN1; SMN2 (0.74) | KDM4EMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL29382304 | 0.75 | SMN1; SMN2 (0.74) | KDM4EMAPTHPGDPOLBSMN1; SMN2 | |
| SCHEMBL5423878 | 0.75 | ALDH1A1 (0.57) | KDM4EMAPTHPGDPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063240-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF AURORA KINASE | ARROW THERAPEUTICS LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |