Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 5/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 7/20 | 0.59 |
| ▸ | ESR1 | P03372 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091247 | 0.89 | HSD17B1 (0.81) | HSD17B1ESR2ESR1MAPTSMN1; SMN2 | |
| SCHEMBL7166892 | 0.86 | HSD17B1 (0.75) | HSD17B1ESR2ESR1SMN1; SMN2HSD17B10 | |
| SCHEMBL439874 | 0.82 | ESR2 (0.76) | HSD17B1ESR2ESR1HSD17B10FGFR1 | |
| SCHEMBL29738442 | 0.82 | ESR2 (0.76) | HSD17B1ESR2ESR1HSD17B10FGFR1 | |
| SCHEMBL2561933 | 0.82 | HSD17B1 (0.70) | HSD17B1ESR1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL497983 | 0.81 | HSD17B1 (0.69) | HSD17B1ESR2ESR1MAPTHSD17B10 | |
| SCHEMBL11705750 | 0.81 | HSD17B1 (0.68) | HSD17B1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13864591 | 0.81 | HSD17B1 (0.68) | HSD17B1ESR2ESR1MAPTSMN1; SMN2 | |
| SCHEMBL2718119 | 0.81 | ESR2 (0.73) | HSD17B1ESR2ESR1HSD17B10FGFR1 | |
| SCHEMBL11742725 | 0.80 | HSD17B1 (0.67) | HSD17B1ESR2ESR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186900-A1 | COMPOUND | STERIX LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| US-20090186900-A1 | COMPOUND | STERIX LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| US-20090186900-A1 | COMPOUND | STERIX LIMITED (GB) | 2009-07-23 | — | — | US | disclosed |
| WO-2007096647-A2 | DIARYL COMPOUNDS AS NON-STEROIDAL INHIBITORS OF 17-BETA HYDROXYSTEROID DEHYDROGENASE AND/OR STEROID SULPHATASE FOR THE TREATMENT OF OESTROGEN-RELATED DISEASES SUCH AS HORMONE DEPENDENT BREAST CANCER | STERIX LIMITED (GB) | 2007-08-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186900-A1 | COMPOUND | HSD17B2, HSD17B11, CYP17A1 | HSD17B1 4/4885ESR2 133/4885ESR1 286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.