Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 4/20 | 0.68 |
| ▸ | ESR1 | P03372 | 8/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.54 |
| ▸ | APP | P05067 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10436026 | 0.84 | MAOB (0.55) | HSD17B1APPCYP2C19CYP2C9CYP3A4 | |
| SCHEMBL30747689 | 0.84 | MAOB (0.55) | HSD17B1APPCYP2C19CYP2C9CYP3A4 | |
| SCHEMBL10925015 | 0.83 | HSD17B1 (0.54) | HSD17B1APPKIF11PTGS1MAPT | |
| SCHEMBL2559215 | 0.83 | RARB (0.59) | HSD17B1APPCYP2C19CYP2C9CYP3A4 | |
| SCHEMBL497922 | 0.82 | CA12 (0.58) | HSD17B1ESR1ESR2APPCYP2C19 | |
| SCHEMBL5549813 | 0.81 | MMP1 (0.49) | HSD17B1APPKIF11PTGS1MAPT | |
| SCHEMBL38659424 | 0.81 | ESR1 (0.70) | HSD17B1ESR1ESR2APPCYP2C19 | |
| SCHEMBL28226426 | 0.81 | ESR1 (0.70) | HSD17B1ESR1ESR2APPCYP2C19 | |
| SCHEMBL4101247 | 0.81 | HSD17B1 (1.00) | HSD17B1ESR1ESR2HSD17B2MAPT | |
| SCHEMBL10922772 | 0.79 | RARB (0.52) | HSD17B1KIF11PTGS1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |