SCHEMBL4101351

SCHEMBL4101351

CCOC(=O)COc1ccc(C(=O)CCc2cn(-c3ccc(C)cn3)nc2C(C)C)cc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
ESR1 P03372 1/20 0.35
PTGDR2 Q9Y5Y4 1/20 0.34
NPC1 O15118 3/20 0.34
RAB9A P51151 3/20 0.34
ABCB1 P08183 1/20 0.34
TAS1R3 Q7RTX0 3/20 0.33
TAS1R1 Q7RTX1 3/20 0.33
ALDH1A1 P00352 2/20 0.33
HPGD P15428 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MEN1 O00255 1/20 0.33
CASP1 P29466 1/20 0.33
KMT2A Q03164 1/20 0.33
HSD17B10 Q99714 1/20 0.33
MAPT P10636 4/20 0.33
THRB P10828 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4100532 0.91 PTGDR2 (0.37) LMNAPTGDR2KDM4EMEN1KMT2A
SCHEMBL4097536 0.86 FBP1 (0.35) LMNATAS1R3TAS1R1THRBTHRA
SCHEMBL4096996 0.84 PPARA (0.39)
SCHEMBL4098493 0.82 PPARD (0.40) ESR1PTGDR2NPC1RAB9A
SCHEMBL6035780 0.74 CYP4F2 (0.38) LMNANPC1RAB9AALDH1A1NPSR1
SCHEMBL6035631 0.74 CYP4F2 (0.38) LMNANPC1RAB9AALDH1A1KDM4E
SCHEMBL4101362 0.73 PPARD (0.46)
SCHEMBL6034597 0.72 SMN1; SMN2 (0.47) LMNANPC1RAB9AALDH1A1HPGD
SCHEMBL6034542 0.71 MAPT (0.41) LMNANPC1RAB9AALDH1A1L3MBTL1
SCHEMBL4095608 0.69 PPARD (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta NIPPON CHEMIPHAR CO., LTD. (JP) 2009-09-24 US disclosed
CN-101166720-A Activator of peroxisome proliferator activated receptor delta NIPPON CHEMIPHAR CO (JP) 2008-04-23 CN disclosed
EP-1854784-A1 ACTIVATOR FOR PEROXISOME PROLIFERATOR ACTIVATING RECEPTOR Nippon Chemiphar Co., Ltd. (JP) 2007-11-14 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240058-A1 Activator for Peroxisome Proliferator-Activating Receptor Delta PPARG, PPARA, PPARD LMNA 3213/4885ESR1 193/4885PTGDR2 204/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.