Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 15/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4101800 | 1.00 | HMGCR (0.71) | HMGCR | |
| SCHEMBL13694349 | 1.00 | HMGCR (0.71) | HMGCR | |
| SCHEMBL4114584 | 0.99 | HMGCR (0.70) | HMGCR | |
| SCHEMBL4114568 | 0.99 | HMGCR (0.70) | HMGCR | |
| SCHEMBL13694342 | 0.95 | HMGCR (0.62) | HMGCR | |
| SCHEMBL14283455 | 0.94 | HMGCR (0.71) | HMGCR | |
| SCHEMBL14283406 | 0.94 | HMGCR (0.71) | HMGCR | |
| SCHEMBL4114574 | 0.93 | HMGCR (0.61) | HMGCR | |
| SCHEMBL4103212 | 0.91 | HMGCR (0.58) | HMGCR | |
| SCHEMBL13694351 | 0.91 | HMGCR (0.58) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227602-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. | 2009-09-10 | — | — | US | disclosed |
| EP-1948168-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | Numerate, Inc (US) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007051065-A2 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | NUMERATE, INC. (US) | 2007-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227602-A1 | COMPOSITIONS AND TREATMENTS FOR INHIBITING KINASE AND/OR HMG-COA REDUCTASE | HMGCR, HMGB3, HMGB2 | HMGCR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.