Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 12/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 11/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.40 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104451 | 0.88 | CYP3A4 (0.41) | CYP3A4CYP2D6TLR7 | |
| SCHEMBL4090126 | 0.86 | TLR7 (0.44) | TLR7HPRT1 | |
| SCHEMBL4103638 | 0.85 | TLR7 (0.40) | TLR7HPRT1 | |
| SCHEMBL19508634 | 0.79 | HPRT1 (0.44) | CYP3A4CYP2D6HPRT1 | |
| SCHEMBL4096891 | 0.79 | HPRT1 (0.41) | CYP3A4CYP2D6TLR7HPRT1 | |
| SCHEMBL4094947 | 0.79 | AGER (0.47) | CYP3A4TLR7HPRT1 | |
| SCHEMBL4102048 | 0.79 | TLR7 (0.41) | CYP3A4CYP2D6TLR7HPRT1 | |
| SCHEMBL3924384 | 0.78 | PNP (0.41) | CYP3A4CYP2D6TLR7HPRT1 | |
| SCHEMBL4095261 | 0.77 | FGFR1 (0.37) | CYP3A4CYP2D6TLR7 | |
| SCHEMBL4100830 | 0.76 | SERPINA3 (0.43) | TLR7HPRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338593-B2 | Agonists; Treatment of Hepatitis C virus; phosphinate-substituted purine derivatives | GILEAD SCIENCES, INC. (US) | 2012-12-25 | — | — | US | disclosed |
| US-20090202484-A1 | MODULATORS OF TOLL-LIKE RECEPTOR 7 | GILEAD SCIENCES, INC. (US) | 2009-08-13 | — | — | US | disclosed |
| US-20080008682-A1 | Modulators of toll-like receptor 7 | GILEAD SCIENCES, INC. | 2008-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080008682-A1 | Modulators of toll-like receptor 7 | TLR7, TLR6, TLR3 | CYP3A4 4601/4885CYP2D6 3898/4885TLR7 1/4885 |
| US-20090202484-A1 | MODULATORS OF TOLL-LIKE RECEPTOR 7 | TLR7, TLR6, TLR3 | CYP3A4 4624/4885CYP2D6 3952/4885TLR7 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.