Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 9/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TYMP | P19971 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028425 | 0.79 | KIF11 (0.54) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL7029415 | 0.76 | KDM4E (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL7027018 | 0.76 | PARP1 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL7026650 | 0.76 | PARP1 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL7027027 | 0.73 | PARP1 (0.46) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL10288996 | 0.72 | MPO (0.54) | KDM4EALDH1A1SMN1; SMN2CA12CA9 | |
| SCHEMBL7028805 | 0.72 | KDM4E (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL31275105 | 0.72 | KDM4E (0.60) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL7023677 | 0.72 | PARP1 (0.44) | KDM4EALDH1A1HPGDSMN1; SMN2PARP1 | |
| SCHEMBL2731175 | 0.72 | KDM4E (0.56) | KDM4EALDH1A1HPGDPARP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120129851-A1 | Substituted Quinazoline and Pyrido-Pyrimidine Derivatives | ENDO PHARMACEUTICALS INC. (US) | 2012-05-24 | — | — | US | disclosed |
| WO-2012058671-A1 | SUBSTITUTED QUINAZOLINE AND PYRIDO-PYRIMIDINE DERIVATIVES | ENDO PHARMACEUTICALS INC. (US) | 2012-05-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129851-A1 | Substituted Quinazoline and Pyrido-Pyrimidine Derivatives | MTOR, PIK3CA, PDPK1 | KDM4E 739/4885ALDH1A1 3589/4885HPGD 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.