Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA7 | P43166 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104750 | 1.00 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4109316 | 1.00 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4109318 | 1.00 | MEN1 (0.45) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4112935 | 0.93 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4112937 | 0.93 | KMT2A (0.49) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4115707 | 0.93 | ALDH1A1 (0.48) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4115701 | 0.93 | ALDH1A1 (0.48) | MEN1KMT2ASMN1; SMN2MAPTLMNA | |
| SCHEMBL4110810 | 0.87 | MAPT (0.51) | MEN1KMT2AMAPTMAPK1NPC1 | |
| SCHEMBL4110814 | 0.87 | MAPT (0.51) | MEN1KMT2AMAPTMAPK1NPC1 | |
| SCHEMBL4119799 | 0.87 | EPHX2 (0.45) | MEN1KMT2ASMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | claimed |
| CN-101282926-B | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2011-07-13 | — | — | CN | claimed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | claimed |
| CN-101282926-A | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2008-10-08 | — | — | CN | claimed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | claimed |
| US-20190117596-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | WAYNE STATE UNIVERSITY (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2017190077-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | WAYNE STATE UNIVERSITY (US) | 2017-11-02 | — | — | WO | disclosed |
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | disclosed |
| CN-101282926-B | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2011-07-13 | — | — | CN | disclosed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| CN-101282926-A | S1p3 receptor antagonist | TOA EIYO LTD (JP) | 2008-10-08 | — | — | CN | disclosed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117596-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | S1PR3, S1PR1, S1PR4 | MEN1 1023/4885KMT2A 865/4885SMN1; SMN2 2500/4885 |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | S1PR3, S1PR5, GPR3 | MEN1 1287/4885KMT2A 2082/4885SMN1; SMN2 2497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.