Fludarabine

Fludarabine

SCHEMBL4105

Nc1nc(F)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O.O=P(O)(O)O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of Fludarabine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DPP4 known ✓ P27487 1/20 0.62
NT5E P21589 2/20 0.89
LMNA P02545 1/20 0.89
HIF1A Q16665 1/20 0.89
CA5A P35218 1/20 0.76
ADORA2A P29274 7/20 0.67
ADORA3 P0DMS8 4/20 0.67
ADORA2B P29275 5/20 0.67
ADORA1 P30542 2/20 0.63
MEN1 O00255 1/20 0.62
SLC28A1 O00337 1/20 0.62
MAP3K7 O43318 1/20 0.62
SLC28A2 O43868 1/20 0.62
GAPDH P04406 1/20 0.62
MAPK1 P28482 1/20 0.62
STAT6 P42226 1/20 0.62
PI4KA P42356 1/20 0.62
KMT2A Q03164 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
PI4K2B Q8TCG2 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fludarabine SCHEMBL6342036 1.00 NT5E (0.89) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL31010885 1.00 NT5E (0.89) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL28482317 1.00 NT5E (0.89) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL31010884 1.00 NT5E (0.89) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL2732720 1.00 NT5E (0.89) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL21465082 1.00 NT5E (0.89) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL13046076 0.94 LMNA (1.00) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL12018219 0.94 LMNA (1.00) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL12232219 0.94 LMNA (1.00) NT5ELMNAHIF1ACA5AADORA2A
Fludarabine SCHEMBL13046078 0.94 LMNA (1.00) NT5ELMNAHIF1ACA5AADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 34804 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116209439-B Cereblon protein modulators Saint Jude Children's Research Hospital Ltd. (US) 2026-05-26 CN claimed
WO-2026102332-A1 NERVE AND TUMOR HOMING AGENTS AND METHODS OF USE THEREOF Blaze Bioscience, Inc. (US) 2026-05-15 WO claimed
WO-2026102321-A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF MYELOPROLIFERATIVE NEOPLASMS MARO BIO INC. (US) 2026-05-15 WO claimed
US-20260132141-A1 PROTEIN PHOSPHATASE 2A ACTIVATORS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2026-05-14 US claimed
CN-122028920-A Method for treating hematological cancer 丹娜-法伯癌症研究院 2026-05-12 CN claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
US-20260102373-A1 LYMPH DIRECTING PRODRUGS MONASH UNIVERSITY (AU) 2026-04-16 US claimed
US-20260090997-A1 Lipid Nanoparticles Comprising Nucleic Acids Encoding Therapeutic Genes and Uses in Medical Methods UNIV EMORY (US) 2026-04-02 US claimed
US-20260076872-A1 POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME SIO2 MEDICAL PRODUCTS LLC (US) 2026-03-19 US claimed
EP-4711364-A1 FUSED PYRROLE RING OR FUSED PYRIDINE RING COMPOUND Pharmaengine, Inc. (TW) 2026-03-18 EP claimed
EP-0770143-A1 METHOD TO IDENTIFY TUMOR SUPPRESSOR GENES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1997-05-02 EP claimed
EP-0769967-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND DIAGNOSTIC DEVICE COMPRISING SAME AND THEIR USE UNIVERSITE CATHOLIQUE DE LOUVAIN (BE) 1997-05-02 EP claimed
WO-1996005863-A1 COMPOUNDS, PHARMACEUTICAL COMPOSITION AND DIAGNOSTIC DEVICE COMPRISING SAME AND THEIR USE LA REGION WALLONNE (BE) 1996-02-29 WO claimed
WO-1995034680-A1 METHOD TO IDENTIFY TUMOR SUPPRESSOR GENES THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 1995-12-21 WO claimed
EP-0393575-B1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent SEARLE & CO (US) 1994-03-16 EP claimed
EP-0359347-B1 COVALENTLY-LINKED COMPLEXES AND METHODS FOR ENHANCED CYTOTOXICITY AND IMAGING NEORX CORPORATION (US) 1992-12-23 EP claimed
WO-1992009604-A1 6-AZIDO-2-FLUOROPURINE BERLEX BIOSCIENCES, INC. (US) 1992-06-11 WO claimed
US-5081110-A Method of killing sarcoma cells using fludarabine phosphate and ionizing radiation SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) 1992-01-14 US claimed
EP-0393575-A1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent G.D. Searle & Co. (US) 1990-10-24 EP claimed
EP-0359347-A2 Covalently-linked complexes and methods for enhanced cytotoxicity and imaging NEORX CORPORATION (US) 1990-03-21 EP claimed