Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SELP | P16109 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4105480 | 1.00 | HPGD (0.36) | HPGDIRAK4PDE4BMAP4K4MAPK1 | |
| SCHEMBL4107432 | 0.85 | HPGD (0.40) | HPGDIRAK4PDE4BMAP4K4MAPK1 | |
| SCHEMBL4107426 | 0.85 | HPGD (0.40) | HPGDIRAK4PDE4BMAP4K4MAPK1 | |
| SCHEMBL871646 | 0.85 | TYRO3 (0.47) | IRAK4MAP4K4MAPK1CHEK1IKBKB | |
| SCHEMBL871647 | 0.85 | TYRO3 (0.47) | IRAK4MAP4K4MAPK1CHEK1IKBKB | |
| SCHEMBL13697674 | 0.83 | IRAK4 (0.40) | HPGDIRAK4PDE4BPDE4APDE4D | |
| SCHEMBL870889 | 0.79 | CRHR1 (0.36) | HPGDIRAK4PDE4BPDE4APDE4D | |
| SCHEMBL870890 | 0.79 | CRHR1 (0.36) | HPGDIRAK4PDE4BPDE4APDE4D | |
| SCHEMBL4110540 | 0.79 | MCHR1 (0.40) | HPGDIRAK4PDE4BMAP4K4PDE4A | |
| SCHEMBL4110544 | 0.79 | MCHR1 (0.40) | HPGDIRAK4PDE4BMAP4K4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | ASTRAZENECA AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233907-A1 | Pyridopyrimidine Derivatives and Their Use as PDE4 Inhibitors | PDE4A, PDE4B, PDE12 | HPGD 110/4885IRAK4 167/4885PDE4B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.