Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL870889 | 1.00 | CRHR1 (0.36) | CRHR1CYP3A4CYP2C9KDRPDE4B | |
| SCHEMBL3027294 | 0.87 | CRHR1 (0.41) | CRHR1CYP3A4CYP2C9KDRPDE4B | |
| SCHEMBL3027298 | 0.87 | CRHR1 (0.41) | CRHR1CYP3A4CYP2C9KDRPDE4B | |
| SCHEMBL10271577 | 0.84 | MERTK (0.43) | CRHR1CYP3A4CYP2C9KDRPDE4B | |
| SCHEMBL871647 | 0.79 | TYRO3 (0.47) | TYRO3MERTKFLT3GAS6IRAK4 | |
| SCHEMBL871646 | 0.79 | TYRO3 (0.47) | TYRO3MERTKFLT3GAS6IRAK4 | |
| SCHEMBL4105480 | 0.79 | HPGD (0.36) | CRHR1PDE4BTYRO3PDE4APDE4D | |
| SCHEMBL4105477 | 0.79 | HPGD (0.36) | CRHR1PDE4BTYRO3PDE4APDE4D | |
| SCHEMBL870600 | 0.77 | PDE4D (0.37) | CRHR1PDE4BTYRO3PDE4APDE4D | |
| SCHEMBL871040 | 0.77 | EGFR (0.39) | CRHR1PDE4BPDE4APDE4DHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | ALCON RESEARCH, LTD. | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077801-A1 | Chemical Compounds 637 | PDE4A, PDE4B, PDE3B | CRHR1 2395/4885CYP3A4 116/4885CYP2C9 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.