Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411240 | 1.00 | OPRM1 (0.51) | OPRM1OPRK1OPRD1NPC1RAB9A | |
| SCHEMBL409661 | 1.00 | OPRM1 (0.51) | OPRM1OPRK1OPRD1NPC1RAB9A | |
| SCHEMBL410625 | 1.00 | OPRM1 (0.51) | OPRM1OPRK1OPRD1NPC1RAB9A | |
| SCHEMBL13303644 | 1.00 | OPRM1 (0.51) | OPRM1OPRK1OPRD1NPC1RAB9A | |
| SCHEMBL13303676 | 1.00 | OPRM1 (0.51) | OPRM1OPRK1OPRD1NPC1RAB9A | |
| SCHEMBL17864348 | 0.87 | OPRM1 (0.59) | OPRM1OPRK1OPRD1IDO1MAOB | |
| SCHEMBL1029045 | 0.83 | PSEN1 (0.47) | OPRM1IDO1 | |
| SCHEMBL4148486 | 0.83 | PSEN1 (0.47) | OPRM1IDO1 | |
| SCHEMBL1135026 | 0.83 | PSEN1 (0.47) | OPRM1IDO1 | |
| SCHEMBL354312 | 0.83 | PSEN1 (0.47) | OPRM1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586899-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2017-03-07 | — | — | US | disclosed |
| US-9586899-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2017-03-07 | — | — | US | disclosed |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CORREVIO CANADA CORP. (CA) | 2015-11-26 | — | — | US | disclosed |
| US-9115081-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2015-08-25 | — | — | US | disclosed |
| US-8692002-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2014-04-08 | — | — | US | disclosed |
| US-20130102791-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2013-04-25 | — | — | US | disclosed |
| US-20130090483-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2013-04-11 | — | — | US | disclosed |
| US-8344162-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2013-01-01 | — | — | US | disclosed |
| US-20120271057-A9 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2012-10-25 | — | — | US | disclosed |
| US-20120065408-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2012-03-15 | — | — | US | disclosed |
| US-8080673-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2011-12-20 | — | — | US | disclosed |
| US-20100217014-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2010-08-26 | — | — | US | disclosed |
| US-7754897-B2 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2010-07-13 | — | — | US | disclosed |
| US-20100152464-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2010-06-17 | — | — | US | disclosed |
| US-20070015924-A1 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065408-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | OPRM1 908/4885OPRK1 749/4885OPRD1 739/4885 |
| US-20130102791-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | OPRM1 391/4885OPRK1 679/4885OPRD1 784/4885 |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | OPRM1 391/4885OPRK1 679/4885OPRD1 784/4885 |
| US-20070015924-A1 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CYP2D6, CYP3A43, CYP2F1 | OPRM1 908/4885OPRK1 749/4885OPRD1 739/4885 |
| US-20130090483-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | OPRM1 908/4885OPRK1 749/4885OPRD1 739/4885 |
| US-20100217014-A1 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | OPRM1 908/4885OPRK1 749/4885OPRD1 739/4885 |
| US-20100152464-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | OPRM1 391/4885OPRK1 679/4885OPRD1 784/4885 |
| US-20120271057-A9 | SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOCYCLOHEXYL ETHER COMPOUNDS | CYP2D6, CYP3A43, CYP2F1 | OPRM1 908/4885OPRK1 749/4885OPRD1 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.