Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | SLC22A12 | Q96S37 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106837 | 0.85 | HPGD (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL1030436 | 0.85 | S1PR1 (0.41) | ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL2637992 | 0.82 | SLC22A12 (0.46) | KDM4EALDH1A1SLC22A12HPGDNPSR1 | |
| SCHEMBL1028564 | 0.80 | ALDH1A1 (0.38) | KDM4EALDH1A1SLC22A12HPGDNPSR1 | |
| SCHEMBL4102629 | 0.79 | LMNA (0.44) | ALDH1A1SMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL4118046 | 0.79 | HPGD (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2LMNA | |
| SCHEMBL1030357 | 0.77 | HIF1A (0.45) | KDM4EALDH1A1NPSR1MAPT | |
| SCHEMBL4112216 | 0.74 | PPARG (0.39) | KDM4EALDH1A1SLC22A12HPGDMEN1 | |
| SCHEMBL4103785 | 0.74 | MAPT (0.45) | KDM4EALDH1A1THRBSMN1; SMN2MEN1 | |
| SCHEMBL1030537 | 0.72 | KMT2A (0.38) | ALDH1A1NPSR1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035375-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2009-03-18 | — | — | EP | claimed |
| WO-2007141039-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-13 | — | — | WO | claimed |
| EP-2035375-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007141039-A1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | Grünenthal GmbH (DE) | 2007-12-13 | — | — | WO | disclosed |