SCHEMBL4107296

SCHEMBL4107296

CC(C)(C)OC(=O)N1CCC(OCc2noc(-c3cc4cccnc4s3)n2)CC1

nearest known ligand 0.49

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 10/20 0.49
DTYMK P23919 1/20 0.40
PRMT5 O14744 1/20 0.38
WDR77 Q9BQA1 1/20 0.38
CCNA2 P20248 1/20 0.37
CDK2 P24941 1/20 0.37
FAAH O00519 1/20 0.37
POLB P06746 1/20 0.37
USP30 Q70CQ3 1/20 0.37
CETP P11597 1/20 0.37
MMP13 P45452 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL390988 0.84 GPR119 (0.53) GPR119CCNA2CDK2USP30
SCHEMBL386979 0.84 GPR119 (0.53) GPR119CCNA2CDK2USP30
SCHEMBL4414422 0.82 GPR119 (0.54) GPR119PRMT5WDR77USP30CETP
SCHEMBL4102266 0.82 GPR119 (0.51) GPR119PRMT5WDR77POLBCETP
SCHEMBL4418705 0.81 GPR119 (0.49) GPR119PRMT5WDR77
SCHEMBL4106414 0.80 GPR119 (0.51) GPR119PRMT5WDR77POLBCETP
SCHEMBL1071735 0.80 GPR119 (0.46) GPR119CETP
SCHEMBL4102957 0.80 GPR119 (0.56) GPR119PRMT5WDR77FAAHUSP30
SCHEMBL4418527 0.80 GPR119 (0.58) GPR119PRMT5WDR77CETP
SCHEMBL4420389 0.79 GPR119 (0.49) GPR119MMP13

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090221644-A1 Gpcr Agonists PROSIDION LIMITED (GB) 2009-09-03 US disclosed
US-20090221644-A1 Gpcr Agonists PROSIDION LIMITED (GB) 2009-09-03 US disclosed
US-20090221644-A1 Gpcr Agonists PROSIDION LIMITED (GB) 2009-09-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090221644-A1 Gpcr Agonists GPR119, GCGR, GPR27 GPR119 1/4885DTYMK 4389/4885PRMT5 3682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.