Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.49 |
| ▸ | CHUK | O15111 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.49 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.49 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.49 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4306407 | 0.80 | ADORA3 (0.64) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL13045873 | 0.78 | ADORA1 (0.57) | ADORA2AADORA2BADORA1AURKBHTT | |
| SCHEMBL10118269 | 0.78 | SMN1; SMN2 (0.44) | ADORA2AHTTSMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL27663340 | 0.76 | ADORA1 (0.43) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL27663321 | 0.76 | MAP4K4 (0.44) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL7013023 | 0.76 | ADORA3 (0.65) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL19720089 | 0.75 | PFKFB1 (0.50) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL27682942 | 0.75 | ADORA1 (0.42) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL3743143 | 0.75 | ADORA2A (0.44) | ADORA2AADORA3ADORA2BADORA1MAPK8 | |
| SCHEMBL27682947 | 0.75 | ADORA1 (0.42) | ADORA2AADORA3ADORA2BADORA1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2393552-B1 | A CYANOPYRIMIDINE DERIVATIVE | OTSUKA PHARMA CO LTD (JP) | 2017-12-20 | — | — | EP | disclosed |
| US-9708292-B2 | Cyanopyrimidine derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-9708292-B2 | Cyanopyrimidine derivative | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-07-18 | — | — | US | disclosed |
| CN-102307621-B | Cyanopyrimidine Derivatives | OTSUKA PHARMACEUTICAL CO.,LTD. (JP) | 2014-10-01 | — | — | CN | disclosed |
| US-20120022077-A1 | NOVEL CYANOPYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-26 | — | — | US | disclosed |
| US-20120022077-A1 | NOVEL CYANOPYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2012-01-26 | — | — | US | disclosed |
| CN-102307621-A | Novel cyanopyrimidine derivative | OTSUKA PHARMA CO LTD | 2012-01-04 | — | — | CN | disclosed |
| EP-2393552-A1 | A NOVEL CYANOPYRIMIDINE DERIVATIVE | Otsuka Pharmaceutical Co., Ltd. (JP) | 2011-12-14 | — | — | EP | disclosed |
| WO-2010090299-A1 | A NOVEL CYANOPYRIMIDINE DERIVATIVE | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120022077-A1 | NOVEL CYANOPYRIMIDINE DERIVATIVE | ADORA2A, ADORA1, ADORA3 | ADORA2A 1/4885ADORA3 3/4885ADORA2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.