Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 12/20 | 0.41 |
| ▸ | TUBB | P07437 | 12/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 12/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 12/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 12/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 12/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 12/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 12/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 12/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 12/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 12/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 12/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 12/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 12/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 12/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4111889 | 0.90 | TUBB4A (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4122687 | 0.83 | L3MBTL1 (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4110749 | 0.83 | GAA (0.39) | — | |
| SCHEMBL4132642 | 0.83 | FNTA (0.39) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13775477 | 0.82 | FNTA (0.38) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13775453 | 0.80 | TUBB4A (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL4121572 | 0.79 | KDM4E (0.35) | KDM4ENPC1ALDH1A1LMNARAB9A | |
| SCHEMBL4121567 | 0.79 | KDM4E (0.35) | KDM4ENPC1ALDH1A1LMNARAB9A | |
| SCHEMBL13775474 | 0.78 | FNTA (0.38) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13775798 | 0.78 | CYP19A1 (0.44) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | TUBB4A 4303/4885TUBB 3846/4885TUBA3C 4443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.