Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.47 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.44 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122330 | 0.93 | KMT2A (0.46) | L3MBTL1HDAC1ALDH1A1HTTCACNA1G | |
| SCHEMBL4124081 | 0.93 | CACNA1G (0.54) | L3MBTL1HDAC1ALDH1A1CACNA1GCACNA1H | |
| SCHEMBL4129333 | 0.92 | MEN1 (0.48) | L3MBTL1ALDH1A1HTTCACNA1GCACNA1H | |
| SCHEMBL4116625 | 0.90 | ELOVL1 (0.49) | L3MBTL1ALDH1A1CACNA1GCACNA1HCACNA1I | |
| SCHEMBL4116848 | 0.90 | KMT2A (0.48) | L3MBTL1HDAC1ALDH1A1CACNA1GCACNA1H | |
| SCHEMBL4116873 | 0.89 | KMT2A (0.42) | L3MBTL1HDAC1ALDH1A1LMNAPKM | |
| SCHEMBL4117091 | 0.88 | CSNK1D (0.47) | L3MBTL1HDAC1ALDH1A1CACNA1GCACNA1H | |
| SCHEMBL13653572 | 0.87 | HDAC4 (0.46) | L3MBTL1ALDH1A1LMNAMAPTNPSR1 | |
| SCHEMBL4110014 | 0.85 | CFTR (0.52) | ALDH1A1NPC1RAB9A | |
| SCHEMBL15108965 | 0.85 | MAPT (0.42) | L3MBTL1ALDH1A1ELOVL1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227615-B2 | Pyridyl derivatives as CFTR modulators | VERTEX PHARMACEUTICAL INCORPORATED (US) | 2012-07-24 | — | — | US | disclosed |
| US-20090246137-A1 | PYRIDYL DERIVATIVES AS CFTR MODULATORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090246137-A1 | PYRIDYL DERIVATIVES AS CFTR MODULATORS | CFTR, ABCC4, ABCB1 | L3MBTL1 4010/4885HDAC1 3182/4885ALDH1A1 2452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.