Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.60 |
| ▸ | HRH1 | P35367 | 2/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | LSS | P48449 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8861752 | 0.96 | HTR2A (0.60) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Bromide SCHEMBL190865 | 0.96 | HTR2A (0.60) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Bromide SCHEMBL246032 | 0.94 | HTR2A (0.58) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Bromide SCHEMBL28158895 | 0.92 | HTR2A (0.56) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Bromide SCHEMBL8909571 | 0.90 | HTR2A (0.53) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Hydrochloric Acid SCHEMBL9549516 | 0.90 | HTR2A (0.53) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Bromide SCHEMBL8782143 | 0.89 | HTR2A (0.52) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Iodide SCHEMBL9549744 | 0.88 | HIF1A (0.58) | HTR2AHRH1HIF1AALDH1A1CYP1A2 | |
| Bromide SCHEMBL9147651 | 0.87 | HTR2A (0.50) | HTR2AHRH1HIF1ASIGMAR1CHRNA7 | |
| Acetic Acid SCHEMBL9549706 | 0.86 | HTR2A (0.50) | HTR2AHRH1HIF1ASIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612219-B2 | 11—[ (Z) -3- (dimethylamino) propylidene]—6, 11-dihydro-dibenz [B,E] oxepin-2-YI ]—acetic acid | URQUIMA S.A. (ES) | 2009-11-03 | — | — | US | disclosed |
| WO-2009081417-A2 | PROCESS FOR PREPARATION OF OLOPAT ADINE HYDROCHLORIDE | INDOCO REMEDIES LIMITED (IN) | 2009-07-02 | — | — | WO | disclosed |
| US-20090005579-A1 | 11 - [ (Z) -3- (Dimethylamino) Propylidene] - 6, 11-Dihydro-Dibenz [B,E] Oxepin-2-Yl] - Acetic Acid | URQUIMA S.A. (ES) | 2009-01-01 | — | — | US | disclosed |
| EP-1908758-A1 | Process for the preparation of (Z)-[11-(3-dimethylamino-propyliden)-6,11-dihydro-dibenzo[b,e]oxepin-2-yl]-acetic acid hydrochloride | Urquima S.A. (ES) | 2008-04-09 | — | — | EP | disclosed |
| EP-1778665-A1 | PROCESS FOR THE PREPARATION OF 11-[(Z)-3-(DIMETHYLAMINO)PROPYLIDENE]-6,11-DIHYDRO-DIBENZ[B,E]OXEPIN-2-YL]ACETIC ACID | Urquima S.A. (ES) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006010459-A1 | PROCESS FOR THE PREPARATION OF 11-[(Z)-3-(DIMETHYLAMINO)PROPYLIDENE]-6,11-DIHYDRO-DIBENZ[B,E]OXEPIN-2-YL]-ACETIC ACID | URQUIMA S.A. (ES) | 2006-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090005579-A1 | 11 - [ (Z) -3- (Dimethylamino) Propylidene] - 6, 11-Dihydro-Dibenz [B,E] Oxepin-2-Yl] - Acetic Acid | OPRD1, OPRK1, MAOB | HTR2A 156/4885HRH1 50/4885HIF1A 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.