Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cetirizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 1.00 |
| ▸ | DRD3 | P35462 | 4/20 | 0.98 |
| ▸ | USP2 | O75604 | 3/20 | 0.98 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.98 |
| ▸ | HRH2 | P25021 | 2/20 | 0.98 |
| ▸ | HTR2A | P28223 | 2/20 | 0.98 |
| ▸ | HTR2B | P41595 | 2/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.98 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.98 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.98 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.98 |
| ▸ | TEK | Q02763 | 1/20 | 0.98 |
| ▸ | DRD2 | P14416 | 3/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.73 |
| ▸ | DRD4 | P21917 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levocetirizine SCHEMBL144375 | 1.00 | HRH1 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Cetirizine SCHEMBL17800801 | 1.00 | HRH1 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Cetirizine SCHEMBL41107 | 1.00 | HRH1 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Levocetirizine SCHEMBL2255374 | 1.00 | HRH1 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Cetirizine SCHEMBL5520719 | 1.00 | HRH1 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Levocetirizine SCHEMBL4914 | 0.99 | DRD3 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Levocetirizine SCHEMBL5935097 | 0.99 | DRD3 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Cetirizine SCHEMBL13724610 | 0.99 | DRD3 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Cetirizine SCHEMBL4176 | 0.99 | DRD3 (1.00) | HRH1DRD3USP2TDP1HRH2 | |
| Cetirizine SCHEMBL2455487 | 0.99 | DRD3 (1.00) | HRH1DRD3USP2TDP1HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6954 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4654949-A1 | USE OF VITAMIN E TPGS AS A TASTE MASKING AGENT FOR BITTER DRUGS | Hyloris Developments SA (BE) | 2025-12-03 | — | — | EP | claimed |
| US-12390416-B2 | Chewable pharmaceutical dosage forms | USpharma Ltd (US) | 2025-08-19 | — | — | US | claimed |
| CN-116440070-B | Cetirizine hydrochloride oral solution composition and preparation method thereof | 成都倍特药业股份有限公司 | 2025-06-24 | — | — | CN | claimed |
| CN-118948852-B | Cetirizine hydrochloride oral liquid, preparation process and application | 常州市儿童医院(常州市第六人民医院) | 2025-05-27 | — | — | CN | claimed |
| CN-120028459-A | Method for detecting content of cetirizine hydrochloride and bacteriostat in cetirizine hydrochloride drops | 江苏天士力帝益药业有限公司 | 2025-05-23 | — | — | CN | claimed |
| CN-119925372-A | Stable cetirizine hydrochloride drops and preparation method thereof | 江苏天士力帝益药业有限公司 | 2025-05-06 | — | — | CN | claimed |
| CN-119546336-A | Allo-low immunity bionic nano vesicle for treating cancer | T·马尔科姆 | 2025-02-28 | — | — | CN | claimed |
| CN-119523890-A | Stable cetirizine hydrochloride pharmaceutical compositions for ophthalmic use | 江苏东科康德药业有限公司 | 2025-02-28 | — | — | CN | claimed |
| CN-119391408-A | Preparation of L/J-CDs-based ratio fluorescent probe and application of L/J-CDs-based ratio fluorescent probe to cetirizine hydrochloride detection | 中国药科大学 | 2025-02-07 | — | — | CN | claimed |
| CN-114487139-B | Detection method of cetirizine hydrochloride related substances | 鲁南制药集团股份有限公司 | 2025-01-14 | — | — | CN | claimed |
| WO-2000070949-A1 | METHOD FOR USING SOLUBLE CURCUMIN TO INHIBIT PHOSPHORYLASE KINASE IN INFLAMMATORY DISEASES | HENG MADALENE C Y (US) | 2000-11-30 | — | — | WO | claimed |
| US-5993833-A | Histamine antagonist, an interleukin-1 antagonist and/or a TNF alpha antagonist in a cosmetic, pharmaceutical or dermatological composition | SOCIETE L'OREAL S.A. (FR) | 1999-11-30 | — | — | US | claimed |
| EP-0765668-B1 | Extract of Iridaceas and compositions containing it | OREAL (FR) | 1999-03-17 | — | — | EP | claimed |
| US-5795574-A | COSMETICS WITH SUBSTANCE P ANTAGONIST | SOCIETE L'OREAL S.A. (FR) | 1998-08-18 | — | — | US | claimed |
| EP-0761204-B1 | Use of extracts of filamentous, non photosynthetic bacteria and the composition containing them | OREAL (FR) | 1998-04-15 | — | — | EP | claimed |
| US-5658948-A | LYSINE; HISTIDINE | ALLERGAN (US) | 1997-08-19 | — | — | US | claimed |
| WO-1997009056-A1 | EXTRACT OF IRIDACEAE AND COMPOSITIONS CONTAINING SUCH EXTRACT | L'OREAL (FR) | 1997-03-13 | — | — | WO | claimed |
| WO-1997009032-A1 | UTILIZATION OF AN EXTRACT OF A NON PHOTOSYNTHETIC FILAMENTARY BACTERIUM AND COMPOSITION CONTAINING SUCH EXTRACT | L'OREAL (FR) | 1997-03-13 | — | — | WO | claimed |
| EP-0761204-A1 | Use of extracts of filamentous, non photosynthetic bacteria and the composition containing them | L'OREAL (FR) | 1997-03-12 | — | — | EP | claimed |
| US-5504113-A | INCLUDING L-ARGININE IN AMOUNT SUFFICIENT TO INTERFERE WITH INTERACTION BETWEEN DRUG AND PRESERVATIVE | ALLERGAN, INC. (US) | 1996-04-02 | — | — | US | claimed |