Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 4/20 | 0.37 |
| ▸ | PREP | P48147 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.32 |
| ▸ | METTL14 | Q9HCE5 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4098418 | 0.90 | P2RX7 (0.39) | P2RX7BCHEACHEPREPNPC1 | |
| Hydrochloric Acid SCHEMBL4113599 | 0.89 | SMN1; SMN2 (0.38) | P2RX7BCHEACHEPREPNPC1 | |
| Hydrochloric Acid SCHEMBL4098070 | 0.84 | P2RX7 (0.38) | P2RX7BCHEACHEPREPNPC1 | |
| Hydrochloric Acid SCHEMBL4109078 | 0.83 | MAPK10 (0.46) | P2RX7BCHEACHEPREP | |
| SCHEMBL4829233 | 0.82 | MAPK10 (0.47) | P2RX7BCHEACHE | |
| Hydrochloric Acid SCHEMBL4103480 | 0.81 | P2RX7 (0.36) | P2RX7BCHEACHEPREPNPC1 | |
| SCHEMBL4892415 | 0.80 | SMN1; SMN2 (0.36) | P2RX7BCHEACHEPREPNPC1 | |
| Hydrochloric Acid SCHEMBL4102832 | 0.79 | P2RX7 (0.34) | P2RX7BCHEACHEPREPNPC1 | |
| Hydrochloric Acid SCHEMBL4109295 | 0.79 | P2RX7 (0.40) | P2RX7BCHEACHEPREPNPC1 | |
| SCHEMBL4900648 | 0.78 | SCN1A (0.35) | P2RX7BCHEACHEPREPNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221829-A1 | 3,4-Dihydroisoquinolinium Salt Derivatives | HANWHA CHEMICAL CORPORATION (KR) | 2009-09-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221829-A1 | 3,4-Dihydroisoquinolinium Salt Derivatives | KCNQ3, KCNQ1, KCNQ2 | ACHE 984/4885P2RX7 2386/4885BCHE 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.