Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 17/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 8/20 | 0.53 |
| ▸ | OGFRL1 | Q5TC84 | 8/20 | 0.47 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4114247 | 1.00 | OPRM1 (0.53) | OPRM1OPRL1OGFRL1ESR1 | |
| SCHEMBL4114251 | 1.00 | OPRM1 (0.53) | OPRM1OPRL1OGFRL1ESR1 | |
| SCHEMBL4110187 | 0.87 | OPRM1 (0.55) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL4115811 | 0.85 | OPRM1 (0.51) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL4105970 | 0.83 | OPRM1 (0.49) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL4111302 | 0.83 | OPRM1 (0.48) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL3409447 | 0.81 | OPRM1 (0.47) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL4121703 | 0.78 | OPRM1 (0.57) | OPRM1OPRL1OGFRL1 | |
| SCHEMBL4114993 | 0.78 | OPRM1 (0.59) | OPRM1OPRL1OGFRL1 | |
| Grt-6010 SCHEMBL518255 | 0.74 | OPRM1 (0.63) | OPRM1OPRL1OGFRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288430-B2 | Spiro(5.5)undecane derivatives | GRUNENTHAL GMBH (DE) | 2012-10-16 | — | — | US | claimed |
| EP-2257526-B1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2011-12-14 | — | — | EP | claimed |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | claimed |
| US-8288430-B2 | Spiro(5.5)undecane derivatives | GRUNENTHAL GMBH (DE) | 2012-10-16 | — | — | US | disclosed |
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | GRUNENTHAL GMBH (DE) | 2009-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247505-A1 | SPIRO(5.5)UNDECANE DERIVATIVES | OPRL1, OPRD1, OPRM1 | OPRM1 3/4885OPRL1 1/4885OGFRL1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.