Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSF1 | Q00613 | 1/20 | 0.64 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.60 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23931958 | 0.91 | PIN1 (0.60) | HSF1PIN1MAPTNOS1KDR | |
| SCHEMBL6789738 | 0.85 | HSF1 (0.72) | HSF1MKNK1POLBMAPTMAOB | |
| SCHEMBL12612614 | 0.82 | PIN1 (0.58) | HSF1PIN1POLBMAPTMAOB | |
| SCHEMBL16638034 | 0.81 | ROCK2 (0.64) | MKNK1ROCK2ROCK1KDREGFR | |
| SCHEMBL6787283 | 0.80 | HSF1 (0.72) | HSF1MKNK1POLBMAPTMAOB | |
| SCHEMBL29695654 | 0.80 | HSF1 (0.65) | HSF1MKNK1POLBMAPTMAOB | |
| SCHEMBL657293 | 0.79 | ROCK2 (0.61) | MKNK1ROCK2ROCK1SYK | |
| SCHEMBL2442475 | 0.79 | MKNK1 (0.59) | MKNK1MAPTROCK2ROCK1KDR | |
| SCHEMBL15639737 | 0.79 | MKNK1 (0.55) | MKNK1ROCK2ROCK1KDREGFR | |
| SCHEMBL29974061 | 0.79 | PIN1 (0.79) | PIN1POLBMAPTGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063240-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF AURORA KINASE | ARROW THERAPEUTICS LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |