SCHEMBL4116387

SCHEMBL4116387

COc1cccc(C2SC(CC(=O)OC(C)C)C(=O)Nc3ccc(Cl)cc32)c1OC

nearest known ligand 0.44

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CDYL2 Q8N8U2 1/20 0.44
CDYL Q9Y232 1/20 0.44
FDFT1 P37268 10/20 0.41
TSHR P16473 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.37
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13776093 1.00 CDYL2 (0.44) CDYL2CDYLFDFT1TSHRSMN1; SMN2
SCHEMBL4117252 0.92 CDYL2 (0.44) CDYL2CDYLFDFT1TSHRMEN1
SCHEMBL4117260 0.92 CDYL2 (0.44) CDYL2CDYLFDFT1TSHRMEN1
SCHEMBL4117257 0.92 CDYL2 (0.44) CDYL2CDYLFDFT1TSHRMEN1
SCHEMBL4123398 0.92 CDYL2 (0.46) CDYL2CDYLFDFT1MEN1KMT2A
SCHEMBL4710206 0.92 CDYL2 (0.46) CDYL2CDYLFDFT1MEN1KMT2A
SCHEMBL4112411 0.92 CDYL2 (0.46) CDYL2CDYLFDFT1MEN1KMT2A
SCHEMBL4112406 0.92 CDYL2 (0.46) CDYL2CDYLFDFT1MEN1KMT2A
SCHEMBL4129636 0.92 CDYL2 (0.43) CDYL2CDYLFDFT1TSHRMEN1
SCHEMBL4710208 0.92 CDYL2 (0.46) CDYL2CDYLFDFT1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090181942-A1 TRICYCLIC COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1939205-A1 TRICYCLIC COMPOUND Daiichi Sankyo Company, Limited (JP) 2008-07-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181942-A1 TRICYCLIC COMPOUNDS FDFT1, COASY, HMGCR CDYL2 1908/4885CDYL 1152/4885FDFT1 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.