SCHEMBL4112406

SCHEMBL4112406

COC(=O)C[C@@H]1S[C@@H](c2cccc(OC)c2OC)c2cc(Cl)ccc2NC1=O

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CDYL2 Q8N8U2 1/20 0.46
CDYL Q9Y232 1/20 0.46
HTT P42858 1/20 0.43
HSD17B10 Q99714 1/20 0.43
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
FDFT1 P37268 3/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4112411 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL4123403 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL4710205 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL4112415 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL4710208 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL4123398 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL4710206 1.00 CDYL2 (0.46) CDYL2CDYLHTTHSD17B10MEN1
SCHEMBL13776093 0.92 CDYL2 (0.44) CDYL2CDYLMEN1KMT2AFDFT1
SCHEMBL4116387 0.92 CDYL2 (0.44) CDYL2CDYLMEN1KMT2AFDFT1
SCHEMBL4123249 0.91 CDYL2 (0.46) CDYL2CDYLFDFT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090181942-A1 TRICYCLIC COMPOUNDS DAIICHI SANKYO COMPANY, LIMITED (JP) 2009-07-16 US disclosed
EP-1939205-A1 TRICYCLIC COMPOUND Daiichi Sankyo Company, Limited (JP) 2008-07-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090181942-A1 TRICYCLIC COMPOUNDS FDFT1, COASY, HMGCR CDYL2 1908/4885CDYL 1152/4885HTT 1777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.