Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.44 |
| ▸ | SI | P14410 | 1/20 | 0.44 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28259907 | 0.88 | FAAH (0.40) | ALDH1A1HDAC1DPP4SMN1; SMN2HDAC8 | |
| SCHEMBL30620176 | 0.86 | KMT2A (0.43) | GAAMGAMSIMGAM2NLRP3 | |
| SCHEMBL15490071 | 0.86 | KMT2A (0.43) | GAAMGAMSIMGAM2NLRP3 | |
| SCHEMBL18751641 | 0.86 | FAAH (0.45) | MEN1ALDH1A1KMT2ATDP1SMN1; SMN2 | |
| SCHEMBL27791252 | 0.86 | MGAM (0.33) | GAAMGAMSIMGAM2NLRP3 | |
| SCHEMBL725284 | 0.85 | DPP4 (0.41) | GAAMGAMSIMGAM2MEN1 | |
| SCHEMBL30167907 | 0.85 | DPP4 (0.41) | GAAMGAMSIMGAM2MEN1 | |
| SCHEMBL28482640 | 0.84 | FAAH (0.54) | — | |
| SCHEMBL5643889 | 0.83 | ALDH1A1 (0.47) | GAAMGAMSIMGAM2MEN1 | |
| SCHEMBL5567382 | 0.83 | MAPT (0.42) | GAAMGAMSIMGAM2NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021118137-A1 | METHOD FOR ENZYMATICALLY PRODUCING BETA AMINO ACID USING NOVEL ESTER HYDROLASE | 건국대학교 산학협력단 | 2021-06-17 | — | — | WO | claimed |
| CN-119039260-A | Epigenetic medicine for enhancing anticancer effect of pali antitumor agent and application thereof | 山东铂源药业股份有限公司 | 2024-11-29 | — | — | CN | disclosed |
| CN-116947638-A | Method for preparing sitagliptin intermediate by one-pot method | 淄博飞源化工有限公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116622658-A | Beta-amino acid dehydrogenase mutant and application thereof in synthesis of aromatic beta-amino acid compound | 中国科学院天津工业生物技术研究所 | 2023-08-22 | — | — | CN | disclosed |
| CN-115583935-A | Preparation method of 4- (2, 4, 5-trifluorophenyl) -3-oxybutyrate ester | 浙江工业大学 | 2023-01-10 | — | — | CN | disclosed |
| CN-113846131-A | Method for preparing (R) -3-amino-4- (2,4, 5-trifluorophenyl) -butyric acid | 尚科生物医药（上海）有限公司 | 2021-12-28 | — | — | CN | disclosed |
| WO-2021118137-A1 | METHOD FOR ENZYMATICALLY PRODUCING BETA AMINO ACID USING NOVEL ESTER HYDROLASE | 건국대학교 산학협력단 | 2021-06-17 | — | — | WO | disclosed |
| WO-2021118137-A1 | METHOD FOR ENZYMATICALLY PRODUCING BETA AMINO ACID USING NOVEL ESTER HYDROLASE | 건국대학교 산학협력단 | 2021-06-17 | — | — | WO | disclosed |
| EP-3156391-B1 | METHOD FOR PREPARING SITAGLIPTIN INTERMEDIATE VIA ASYMMETRICAL REDUCTION METHOD | ZHEJIANG HUAHAI PHARM CO LTD (CN) | 2020-09-02 | — | — | EP | disclosed |
| CN-107311862-B | Preparation method of sitagliptin intermediate | 南京红杉生物科技有限公司 | 2020-06-19 | — | — | CN | disclosed |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2010-10-28 | — | — | US | disclosed |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2010-10-28 | — | — | US | disclosed |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2010-10-28 | — | — | US | disclosed |
| EP-2230241-A1 | TETRAHYDRO-IMIDAZOÝ1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-09-22 | — | — | EP | disclosed |
| EP-2230241-A1 | TETRAHYDRO-IMIDAZOÝ1,5-A¨PYRAZINE DERIVATIVES, PREPARATION METHODS AND MEDICAL USES THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2010-09-22 | — | — | EP | disclosed |
| CN-101641361-A | Tetrahydroimidazo [1, 5-a ] pyrazine derivative, preparation method and application thereof in medicine | SHANGHAI HENGRUI PHARM CO LTD | 2010-02-03 | — | — | CN | disclosed |
| CN-101641360-A | Piperazine derivatives, preparation method and medical application thereof | SHANGHAI HENGRUI PHARM CO LTD | 2010-02-03 | — | — | CN | disclosed |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-07-30 | — | — | US | disclosed |
| US-20090192326-A1 | Preparation of sitagliptin intermediate | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-07-30 | — | — | US | disclosed |
| WO-2009064476-A1 | PREPARATION OF SITAGLIPTIN INTERMEDIATE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090192326-A1 | Preparation of sitagliptin intermediate | DPP4, DPP7, DPP3 | GAA 609/4885MGAM 472/4885SI 7/4885 |
| US-20100273786-A1 | TETRAHYDRO-IMIDAZ0[1,5-A]PYRAZINE DERIVATIVES, PREPARATION PROCESS AND MEDICINAL USE THEREOF | DPP4, DPP7, DPP3 | GAA 247/4885MGAM 198/4885SI 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.