Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | RAPGEF3 | O95398 | 4/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118686 | 1.00 | MAOB (0.47) | MAOBS1PR3MEN1KMT2ARAPGEF3 | |
| SCHEMBL4110007 | 0.91 | S1PR3 (0.49) | S1PR3MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL4110003 | 0.91 | S1PR3 (0.49) | S1PR3MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL4102776 | 0.90 | S1PR3 (0.48) | S1PR3MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4102773 | 0.90 | S1PR3 (0.48) | S1PR3MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL4115659 | 0.88 | S1PR3 (0.50) | S1PR3MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL4121105 | 0.88 | S1PR3 (0.41) | S1PR3MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL4115661 | 0.88 | S1PR3 (0.50) | S1PR3MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL4121107 | 0.88 | S1PR3 (0.41) | S1PR3MEN1KMT2ARAPGEF3RAPGEF4 | |
| SCHEMBL4115701 | 0.88 | ALDH1A1 (0.48) | MEN1KMT2AMAPTALDH1A1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | claimed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | claimed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | claimed |
| US-20190117596-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | WAYNE STATE UNIVERSITY (US) | 2019-04-25 | — | — | US | disclosed |
| WO-2017190077-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | WAYNE STATE UNIVERSITY (US) | 2017-11-02 | — | — | WO | disclosed |
| US-8546452-B2 | S1P3 receptor antagonist | TOA EIYO LTD. (JP) | 2013-10-01 | — | — | US | disclosed |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2009-07-02 | — | — | US | disclosed |
| EP-1935874-A1 | S1P3 RECEPTOR ANTAGONIST | TOA EIYO LTD. (JP) | 2008-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117596-A1 | TY-52156 COMPOUNDS FOR THE TREATMENT OF CANCER | S1PR3, S1PR1, S1PR4 | MAOB 4686/4885S1PR3 1/4885MEN1 1023/4885 |
| US-20090170895-A1 | S1P3 RECEPTOR ANTAGONIST | S1PR3, S1PR5, GPR3 | MAOB 4062/4885S1PR3 1/4885MEN1 1287/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.