Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | HSPA5 | P11021 | 6/20 | 0.55 |
| ▸ | HSPA9 | P38646 | 3/20 | 0.55 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | HSPA2 | P54652 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119851 | 0.83 | HSPA5 (0.57) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL12884426 | 0.83 | LMNA (0.58) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL6056907 | 0.83 | HSPA5 (0.57) | LMNATSHRHSPA5HSPA9FFAR2 | |
| Hydrochloric Acid SCHEMBL7422746 | 0.81 | HSPA5 (0.56) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL1107000 | 0.80 | ADORA2A (0.68) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL7873389 | 0.78 | HSPA5 (0.53) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL23804604 | 0.77 | LMNA (0.59) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL7876872 | 0.77 | LMNA (0.59) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL27891187 | 0.77 | FFAR2 (0.62) | LMNATSHRHSPA5HSPA9FFAR2 | |
| SCHEMBL592704 | 0.76 | MEN1 (0.65) | MEN1KMT2ANR3C1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431565-B2 | Substituted imidazoheterocycles | CARA THERAPEUTICS, INC. (US) | 2013-04-30 | — | — | US | claimed |
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CARA THERAPEUTICS, INC. (US) | 2009-06-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149450-A1 | SUBSTITUTED IMIDAZOHETEROCYCLES | CNR1, CNR2, TRPV1 | LMNA 3582/4885TSHR 1095/4885HSPA5 2974/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.