Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | NQO1 | P15559 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15851182 | 0.95 | CYP1A2 (0.55) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL18810297 | 0.95 | CYP1A2 (0.55) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL12278160 | 0.95 | CYP1A2 (0.55) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL4416705 | 0.84 | PAX8 (0.51) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL16271828 | 0.82 | KDM4E (0.54) | CYP1B1KDM4EMAPTHSD17B10GAA | |
| SCHEMBL18195344 | 0.81 | CYP1A2 (0.62) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL17427932 | 0.81 | PAX8 (0.49) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL12278145 | 0.81 | PAX8 (0.49) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL4418399 | 0.79 | CYP1A2 (0.44) | CYP1A2CYP1A1CYP1B1ACHEKDM4E | |
| SCHEMBL4427615 | 0.79 | CYP1A2 (0.44) | CYP1A2CYP1A1CYP1B1ACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351266-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2008-04-01 | — | — | US | claimed |
| US-20050193504-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER & GAMBLE COMPANY, THE | 2005-09-08 | — | — | US | claimed |
| EP-1741000-B1 | AS-INDACENE DERIVATIVES HAVING NEGATIVE DIELECTRIC ANISOTROPY | MERCK PATENT GMBH (DE) | 2012-12-26 | — | — | EP | disclosed |
| EP-1720615-B1 | COSMETIC HAIR DYEING COMPOSITIONS CONTAINING THEM AND USE THEREOF | PROCTER & GAMBLE (US) | 2009-12-30 | — | — | EP | disclosed |
| US-7517471-B2 | And benzo[1,2-b:3,4-b']difuran derivatives; liquid crystal media, electrooptical displays; negative Delta epsilon, vertically alligned thin film transistors | MERCK PATENT GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| US-7468080-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2008-12-23 | — | — | US | disclosed |
| US-20080134450-A1 | Keratin Dyeing Compounds, Keratin Dyeing Compositions Containing Them, And Use Thereof | WELLA OPERATIONS US, LLC | 2008-06-12 | — | — | US | disclosed |
| US-7351266-B2 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | THE PROCTER & GAMBLE COMPANY (US) | 2008-04-01 | — | — | US | disclosed |
| US-20070228328-A1 | As-Indacen Derivatives | MERCK PATENT GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| EP-1741000-A1 | AS-INDACEN DERIVATIVES | MERCK PATENT GmbH (DE) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005103799-A1 | AS-INDACEN DERIVATIVES | MERCK PATENT GMBH (DE) | 2005-11-03 | — | — | WO | disclosed |
| US-20050193504-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | PROCTER & GAMBLE COMPANY, THE | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050193504-A1 | Keratin dyeing compounds, keratin dyeing compositions containing them, and use thereof | KRT18, CKMT1A; CKMT1B, KRTCAP2 | CYP1A2 640/4885CYP1A1 292/4885CYP1B1 189/4885 |
| US-20080134450-A1 | Keratin Dyeing Compounds, Keratin Dyeing Compositions Containing Them, And Use Thereof | KRT18, CKMT1A; CKMT1B, KRTCAP2 | CYP1A2 640/4885CYP1A1 292/4885CYP1B1 189/4885 |
| US-20070228328-A1 | As-Indacen Derivatives | AXIN2, CYP1B1, IDO2 | CYP1A2 19/4885CYP1A1 16/4885CYP1B1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.