AXIN2 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL16447499	1.00	3/20
SCHEMBL11919906	0.75	3/20
SCHEMBL13048281	0.63	3/20
SCHEMBL27218766	0.63	3/20
SCHEMBL11919934	0.61	3/20
SCHEMBL27218866	0.56	3/20
SCHEMBL11919898	1.00	2/20
SCHEMBL11919903	0.86	2/20
SCHEMBL16010756	0.86	2/20
SCHEMBL11919900	0.83	2/20
SCHEMBL11919910	0.75	2/20
SCHEMBL11919916	0.72	2/20
SCHEMBL11919921	0.72	2/20
SCHEMBL11919902	0.71	2/20
SCHEMBL11919917	0.69	2/20
SCHEMBL11919950	0.68	2/20
SCHEMBL11919951	0.66	2/20
SCHEMBL11919952	0.64	2/20
SCHEMBL11919953	0.64	2/20
SCHEMBL11919930	0.64	2/20

Clinical trials — most relevant to AXIN2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma	PHASE2/PHASE3	ACTIVE_NOT_RECRUITING
Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment	PHASE2/PHASE3	RECRUITING
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer	PHASE2	ACTIVE_NOT_RECRUITING
Foxy-5 as Neo-Adjuvant Therapy in Subjects With Wnt-5a Low Colon Cancer	PHASE2	UNKNOWN
Targeted Therapy With Glycogen Synthase Kinase-3 Inhibition for Arrhythmogenic Cardiomyopathy	PHASE2	RECRUITING
Comparing of Sesame Oil, Nitroglycerin Ointment, and Aloe Vera Gel	PHASE2	NOT_YET_RECRUITING
Mesalazine Effects in Sporadic Colorectal Adenoma Patients	PHASE2	COMPLETED
CTNNB1 Neurodevelopmental Syndrome - Natural History Study	nan	RECRUITING
Aberrant Splicings Due to Microsatellite Instability in Colorectal Cancer : Physiopathological and Clinical Impact	nan	UNKNOWN
Expanded Access Use of DKN-01 for the Treatment of Advanced Solid Tumors	nan	NO_LONGER_AVAILABLE
Predictive Value of E-cadherin, β-catenin and SOX4 in Recurrence and/or Progression of Non-muscle Invasive Urinary Bladder Transitional Cell Carcinoma. A Retrospective Study	nan	COMPLETED
Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE variaTionS	nan	RECRUITING
Prebiotic Effect of Eicosapentaenoic Acid Treatment for Colorectal Cancer Liver Metastases	nan	COMPLETED
Clinical Application of PET Imaging Targeting MSLN in Malignant Tumors	nan	RECRUITING
Genetic Variants of Selected Genes in Colo-Rectal Cancer Patients.	nan	UNKNOWN
Effect of Mechanical Ventilation on Plasma Concentration Level of R-spondin Proteins	nan	COMPLETED
Development of Polygenic Risk Scores in Colon Cancer Patients Through the Study of Ancestry and Diversity in Genetic Maps of the Brazilian Population - ORIGEM Project	nan	ENROLLING_BY_INVITATION
Exploratory Study of Rectal Mucus for Diagnosing Disease	nan	COMPLETED
PRESEPT Study: Evaluation of SEPT9 Biomarker Performance for Colorectal Cancer Screening	nan	COMPLETED
Role of IMP3 Expression in Colorectal Carcinoma: An Immunohistochemical Study	nan	UNKNOWN
Focal Radiotherapy Plus Low Dose Craniospinal Irradiation Followed by Adjuvant Chemotherapy in WNT Medulloblastoma.	nan	RECRUITING
Ohio Colorectal Cancer Prevention Initiative	nan	COMPLETED
CTNNA1 Familial Expansion Study	nan	RECRUITING
Multi-center Controlled Clinical Trials in Alport Syndrome-A Feasibility Study	nan	COMPLETED
Early Check: Expanded Screening in Newborns	nan	ENROLLING_BY_INVITATION
Adherence to Colon Cancer Screening (ACCS)	nan	COMPLETED
Long-Term Health Outcomes in Children Born With Hirschsprung's Disease and Anorectal Malformations at the Colorectal Centre of Excellence in Quebec	nan	ENROLLING_BY_INVITATION
The Activation of Hippo Pathway in Nasal Polyps	nan	UNKNOWN
Clinic, Pathologic and Genetic Characterization of Patients With Familial Carcinoid Tumors (Study From the GTE, Groupe d'étude Des Tumeurs Endocrines)	nan	UNKNOWN
Screening for Hepatitis Virus B Protein X (HBx) in Colitis-associated Cancer (CAC)	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a AXIN2 binder may also engage these)

Protein	Name	Similarity
O88566	—	1.000	O88566 →
O70240	—	1.000	O70240 →
O70239	—	0.998	O70239 →
P57095	—	0.997	P57095 →
O15169	—	0.996	O15169 →
P57094	—	0.994	P57094 →
Q9YGY0	—	0.994	Q9YGY0 →
O35625	—	0.994	O35625 →
Q9Z136	—	0.994	Q9Z136 →
P59281	—	0.992	P59281 →
Q922B9	—	0.992	Q922B9 →
A0M8T5	—	0.992	A0M8T5 →
Q09YM8	—	0.991	Q09YM8 →
Q8K3I4	—	0.991	Q8K3I4 →
Q07E15	—	0.991	Q07E15 →
Q9EP53	—	0.991	Q9EP53 →
Q155Q3	—	0.991	Q155Q3 →
Q09YJ3	—	0.991	Q09YJ3 →
Q9QY01	—	0.991	Q9QY01 →
A5D794	—	0.991	A5D794 →
Q9Y2H5	—	0.991	Q9Y2H5 →
Q09YG9	—	0.991	Q09YG9 →
P59808	—	0.991	P59808 →
Q09YK4	—	0.991	Q09YK4 →
O42400	—	0.991	O42400 →
Q99LJ0	—	0.990	Q99LJ0 →
Q2IBA2	—	0.990	Q2IBA2 →
Q5XJV7	—	0.990	Q5XJV7 →
Q07DV1	—	0.990	Q07DV1 →
Q8R0S2	—	0.990	Q8R0S2 →