Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 6/20 | 0.87 |
| ▸ | USP2 | O75604 | 3/20 | 0.87 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.87 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.87 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.87 |
| ▸ | RECQL | P46063 | 2/20 | 0.87 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.87 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.87 |
| ▸ | EGFR | P00533 | 1/20 | 0.87 |
| ▸ | LCK | P06239 | 1/20 | 0.87 |
| ▸ | FYN | P06241 | 1/20 | 0.87 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.87 |
| ▸ | HTR2A | P28223 | 1/20 | 0.87 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.87 |
| ▸ | YARS1 | P54577 | 2/20 | 0.61 |
| ▸ | KDM6B | O15054 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 2/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL23853065 | 1.00 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL1663799 | 1.00 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL27971720 | 1.00 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL23069646 | 1.00 | SLC7A5 (0.87) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL8579019 | 0.95 | SLC7A5 (0.79) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL8579024 | 0.95 | SLC7A5 (0.79) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL8599507 | 0.94 | SLC7A5 (0.77) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL116907 | 0.93 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL20582239 | 0.93 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 | |
| Levodopa SCHEMBL11000382 | 0.93 | SLC7A5 (1.00) | SLC7A5USP2PTGS1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964190-A | Method for increasing yields of morphinan alkaloids and derivatives | 安思雅公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-108619016-B | Whitening and wrinkle-improving application of aquilaria sinensis | 韩国生命工学研究院 | 2023-03-31 | — | — | CN | disclosed |
| EP-3883612-A1 | BIMODAL NANOPARTICLE CONJUGATES FOR NON-INVASIVE CENTRAL NERVOUS SYSTEM TISSUE IMAGING | The University Of Georgia Research Foundation, Inc. (US) | 2021-09-29 | — | — | EP | disclosed |
| CN-113234049-A | Tyrosinase inhibitor extracted based on grape seeds as well as extraction method and application thereof | 广州纳丽生物科技有限公司 | 2021-08-10 | — | — | CN | disclosed |
| WO-2020204260-A1 | NOVEL BIFIDOBACTERIUM LONGUM STRAIN OR COSMETIC COMPOSITION COMPRISING SAME | (주) 에이투젠 | 2020-10-08 | — | — | WO | disclosed |
| CN-108619016-A | The whitening of Pistacia weinmannifolia and wrinkle improve purposes | 韩国生命工学研究院 | 2018-10-09 | — | — | CN | disclosed |
| CN-105503645-B | Crystal form A of compound 3 (2-acetamido) -propionic acid and preparation method and application thereof | 新钰生技股份有限公司 | 2017-10-24 | — | — | CN | disclosed |
| WO-2017106937-A1 | ENZYMATICALLY ACTIVE SUPRAMOLECULAR ASSEMBLIES | MONASH UNIVERSITY (AU) | 2017-06-29 | — | — | WO | disclosed |
| US-20170166619-A1 | Polypeptide connected with an organic residue | MORPHOPLANT GMBH (DE) | 2017-06-15 | — | — | US | disclosed |
| CN-106667835-A | Natural plant compound with skin whitening function and application of compound in cosmetics | 广东药科大学 | 2017-05-17 | — | — | CN | disclosed |
| WO-2008015342-A2 | USE OF A PLANT EXTRACT AS ACTIVE AGENT FOR INCREASING MELANIN SYNTHESIS IN MELANOCYTES | SOCIETE D'EXTRACTION DES PRINCIPES ACTIFS SA (VINCIENCE) (FR) | 2008-02-07 | — | — | WO | disclosed |
| CN-1719971-A | Transgenic high tryptophan plants | RENESSEN LLC (US) | 2006-01-11 | — | — | CN | disclosed |
| WO-2005097054-A1 | A NOVEL UV-SHIELDING COMPLEX AND PRODUCTION METHOD THEREOF | COTDE INC. (KR) | 2005-10-20 | — | — | WO | disclosed |
| CN-1622824-A | Microbially expressed thermotolerant phytase for animal feed | SYNGENTA PARTICIPATIONS AG (CH) | 2005-06-01 | — | — | CN | disclosed |
| CN-1161126-C | Composition for preparing medicines, beautifying and cosmetics and its application | 姜 宁 | 2004-08-11 | — | — | CN | disclosed |
| WO-2002015871-A1 | USE OF TYRAMINE IN COSMETIC COMPOSITIONS TO LIGHTEN THE SKIN | SEDERMA S.A. (FR) | 2002-02-28 | — | — | WO | disclosed |
| CN-1293038-A | Composition for preparing medicines, beautifying and cosmetics and its application | JIANG NING (CN) | 2001-05-02 | — | — | CN | disclosed |
| US-5856308-A | POLYPEPTIDES; WOUND HEALING AGENTS | HAEMACURE CORPORATION (CA) | 1999-01-05 | — | — | US | disclosed |
| US-5637756-A | TREATMENT OF SKIN DISORDERS, BLEACHING OF PIGMENTED SPOTS, COSMETICS | L'OREAL (FR) | 1997-06-10 | — | — | US | disclosed |
| US-3964871-A | GLUCOSE OXIDASE, HORSERADISH PEROXIDASE | BECTON, DICKINSON AND COMPANY (US) | 1976-06-22 | — | — | US | disclosed |