Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 known ✓ | P35462 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 5/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 5/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 1.00 |
| ▸ | USP2 | O75604 | 4/20 | 1.00 |
| ▸ | RECQL | P46063 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | HTR2A | P28223 | 2/20 | 1.00 |
| ▸ | PTGS2 | P35354 | 2/20 | 1.00 |
| ▸ | EGFR | P00533 | 1/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 1.00 |
| ▸ | FYN | P06241 | 1/20 | 1.00 |
| ▸ | KDM6B | O15054 | 1/20 | 0.66 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | ALPI | P09923 | 1/20 | 0.58 |
| ▸ | XIAP | P98170 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levodopa SCHEMBL24360 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL29373537 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL29974762 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL11000382 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL116907 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL30678311 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL22655 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL29975814 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL20582239 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 | |
| Levodopa SCHEMBL1853441 | 1.00 | SLC7A5 (1.00) | SLC7A5KDM4EALOX15HIF1AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110106708-A | A kind of non-iris structure yarn dyed fabric and preparation method thereof | 苏州大学 | 2019-08-09 | — | — | CN | claimed |
| CN-107858217-A | STABILIZED SUBTILISIN COMPOSITION | 诺维信公司 | 2018-03-30 | — | — | CN | claimed |
| CN-107522827-A | A kind of photocuring 3D printing photosensitive resin and its preparation method and application | 杨军 | 2017-12-29 | — | — | CN | claimed |
| CN-103649292-B | Stabilized subtilisin compositions | 诺维信公司 | 2017-11-28 | — | — | CN | claimed |
| CN-106456665-A | Methods of promoting bone growth and healing | 宾夕法尼亚州研究基金会 | 2017-02-22 | — | — | CN | claimed |
| EP-2911646-A2 | A SUNSCREEN COMPOSITION CONTAINING ESTER SALTS OF L-DOPA | Unilever N.V. (NL) | 2015-09-02 | — | — | EP | claimed |
| WO-2014063906-A2 | A SUNSCREEN COMPOSITION | UNILEVER N.V. (NL) | 2014-05-01 | — | — | WO | claimed |
| US-11912792-B2 | Bicyclic peptide ligands specific for nectin-4 | BICYCLETX LIMITED (GB) | 2024-02-27 | — | — | US | disclosed |
| US-20230287047-A1 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR NECTIN-4 | BICYCLETX LIMITED (GB) | 2023-09-14 | — | — | US | disclosed |
| US-11180531-B2 | Bicyclic peptide ligands specific for Nectin-4 | BICYCLETX LIMITED (GB) | 2021-11-23 | — | — | US | disclosed |
| CN-113423417-A | Compounds for the treatment of parkinson's disease | 约翰内斯堡威特沃特斯兰德大学 | 2021-09-21 | — | — | CN | disclosed |
| EP-3810169-A1 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR NECTIN-4 | BicycleTX Limited (GB) | 2021-04-28 | — | — | EP | disclosed |
| EP-3810167-A1 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR NECTIN-4 | BicycleTX Limited (GB) | 2021-04-28 | — | — | EP | disclosed |
| EP-0247436-B1 | PROCESS FOR RECOVERY OF AMINO ACID FROM AQUEOUS MIXTURES | HENKEL CORPORATION (a Delaware corp.) (US) | 1992-01-08 | — | — | EP | disclosed |
| EP-0399573-A2 | Process for recovery of amino acid from aqueous mixtures | HENKEL CORPORATION (a Delaware corp.) (US) | 1990-11-28 | — | — | EP | disclosed |
| US-4936999-A | CONTACTING WATER IMMISCIBLE QUATERNARY AMMONIUM EXTRACTANT WITH CONCENTRATED ACID SOLUTION AND PRECIPITATING | HENKEL CORPORATION (US) | 1990-06-26 | — | — | US | disclosed |
| US-4886889-A | SOLVENT EXTRACTION, STRIPPING, PRECIPITATION | HENKEL CORPORATION (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0247436-A1 | Process for recovery of amino acid from aqueous mixtures | HENKEL CORPORATION (a Delaware corp.) (US) | 1987-12-02 | — | — | EP | disclosed |
| US-4644067-A | ADDING SULFATE OR SULFONATE; ACIDIFYING | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-02-17 | — | — | US | disclosed |
| EP-0073381-B1 | PROCESS FOR THE EXTRACTION OF AROMATIC AMINO ACIDS FROM THE AQUEOUS PHASE | SCHERING AKTIENGESELLSCHAFT (DE) | 1986-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230287047-A1 | BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR NECTIN-4 | NECTIN4, VCAM1, SIGLEC7 | DRD3 1798/4885SLC7A5 1250/4885KDM4E 3875/4885 |
| US-11912792-B2 | Bicyclic peptide ligands specific for nectin-4 | NECTIN4, VCAM1, SIGLEC7 | DRD3 1798/4885SLC7A5 1250/4885KDM4E 3875/4885 |
| US-11180531-B2 | Bicyclic peptide ligands specific for Nectin-4 | NECTIN4, VCAM1, SIGLEC7 | DRD3 1798/4885SLC7A5 1250/4885KDM4E 3875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.