Levodopa

Levodopa

SCHEMBL22655

N[C@@H](Cc1ccc(O)c(O)c1)C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

DRD3

The experimentally established mechanism targets of Levodopa. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD3 known ✓ P35462 1/20 0.53
SLC7A5 Q01650 6/20 1.00
KDM4E B2RXH2 5/20 1.00
ALOX15 P16050 5/20 1.00
HIF1A Q16665 5/20 1.00
HSD17B10 Q99714 5/20 1.00
USP2 O75604 4/20 1.00
RECQL P46063 4/20 1.00
TDP1 Q9NUW8 4/20 1.00
PTGS1 P23219 2/20 1.00
ADORA3 P0DMS8 2/20 1.00
HTR2A P28223 2/20 1.00
PTGS2 P35354 2/20 1.00
EGFR P00533 1/20 1.00
LCK P06239 1/20 1.00
FYN P06241 1/20 1.00
KDM6B O15054 1/20 0.66
PKM P14618 3/20 0.58
ALPI P09923 1/20 0.58
XIAP P98170 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Levodopa SCHEMBL24360 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL704089 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL29373537 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL29974762 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL11000382 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL116907 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL30678311 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL29975814 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL20582239 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10
Levodopa SCHEMBL1853441 1.00 SLC7A5 (1.00) SLC7A5KDM4EALOX15HIF1AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 120343 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260146046-A1 BICYCLIC FERROPORTIN INHIBITORS VIFOR (INTERNATIONAL) AG (CH) 2026-05-28 US claimed
EP-4389173-B1 DEVICE FOR SUBCUTANEOUS DELIVERY OF FLUID MEDICAMENT NEURODERM LTD (IL) 2026-05-27 EP claimed
EP-4746852-A1 LIPID AGGREGATES FOR INTRAARTICULAR ADMINISTRATION Universität Bern (CH) 2026-05-27 EP claimed
EP-4746864-A1 C5 KETONE COMPOSITIONS AND RELATED METHODS FOR TREATING METABOLIC DYSFUNCTION Keto Innovations, LLC (US) 2026-05-27 EP claimed
EP-4746858-A2 COATED NANOPARTICLES AND THEIR USE FOR DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS Politecnico Di Torino (IT) 2026-05-27 EP claimed
EP-4747627-A1 METHODS AND SYSTEMS FOR PREDICTIVE CLASSIFICATION BY MASS SPECTROMETRY AND TRAINED LARGE SPECTRAL MODELS Matterworks Inc (US) 2026-05-27 EP claimed
EP-3607938-B1 PHARMACEUTICAL COMPOSITION SOVIC BRKICIC LJILJANA (HR) 2026-05-27 EP claimed
CN-122075447-A Flexible patch for nervous system diseases and preparation method thereof 2026-05-26 CN claimed
CN-122091251-A Method for constructing adverse drug reaction risk prediction model 2026-05-26 CN claimed
CN-122080903-A Foam profile control agent and preparation method and application thereof 2026-05-26 CN claimed
US-3993436-A Dyeing live hair with melanin precursors SHISEIDO CO., LTD. (JA) 1976-11-23 US claimed
US-3991207-A TETRAHYDRONAPHTHYLAMINES AND L-3,4-DIHYDROXYPHENYL-ALANINE PFIZER INC. (US) 1976-11-09 US claimed
US-3988461-A Pharmaceutical composition for the treatment of Parkinson's disease EGYT GYOGYSZERVEGYESZETI GYAR (HU) 1976-10-26 US claimed
US-3983234-A CLOZAPINE SANDOZ LTD. (CH) 1976-09-28 US claimed
US-3972918-A Process for separating DOPA from tyrosine THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1976-08-03 US claimed
US-3969397-A Process for the preparation of l-dopa HOFFMANN-LA ROCHE INC. (US) 1976-07-13 US claimed
US-3964871-A GLUCOSE OXIDASE, HORSERADISH PEROXIDASE BECTON, DICKINSON AND COMPANY (US) 1976-06-22 US claimed
US-3961041-A PARKINSON'S DISEASE INTERX RESEARCH CORPORATION (US) 1976-06-01 US claimed
US-3961060-A DOPA, M-TYROSINE, APOMORPHINE, PIPERAZINE DERIVATIVE ASTRA LAKEMEDAL AKTIEBOLAG (SW) 1976-06-01 US claimed
US-3941835-A Recovery of L-Dopa from R-dopa containing materials BIO-DERIVATIVES CORPORATION (US) 1976-03-02 US claimed