Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4125340 | 0.83 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL10327818 | 0.76 | PIK3CA (0.56) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL10327709 | 0.76 | PIK3CA (0.76) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL10327613 | 0.74 | PIK3CA (0.52) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL3990409 | 0.73 | PIK3CA (0.58) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL10328228 | 0.72 | PIK3CA (0.64) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL13848198 | 0.71 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL13848174 | 0.70 | PIK3CA (0.83) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR | |
| SCHEMBL4116337 | 0.70 | CYP11B2 (0.60) | LMNAHTTPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15334724 | 0.69 | PIK3CA (0.54) | PIK3CAPIK3CBPIK3CGPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009066084-A1 | 2 -MORPHOLINOPYRIMIDINES AND THEIR USE AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-05-28 | — | — | WO | claimed |