Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.38 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27176406 | 0.81 | KCNA5 (0.54) | SMN1; SMN2GAALMNAL3MBTL1SLC6A2 | |
| SCHEMBL27176402 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2GAALMNAL3MBTL1SLC6A2 | |
| SCHEMBL30326956 | 0.78 | SMN1; SMN2 (0.61) | SMN1; SMN2GAALMNAL3MBTL1SLC6A2 | |
| SCHEMBL5386880 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2GAALMNAL3MBTL1SLC6A2 | |
| SCHEMBL2423599 | 0.72 | SMN1; SMN2 (0.57) | SMN1; SMN2GAALMNAL3MBTL1SLC6A2 | |
| SCHEMBL28748 | 0.72 | — | — | |
| SCHEMBL10442614 | 0.72 | CFTR (0.54) | SMN1; SMN2GAALMNAL3MBTL1SLC6A2 | |
| SCHEMBL177932 | 0.72 | — | — | |
| SCHEMBL4098469 | 0.72 | — | — | |
| SCHEMBL31080226 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2064204-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | Merck & Co., Inc. (US) | 2009-06-03 | — | — | EP | claimed |
| WO-2008030369-A1 | INHIBITORS OF 5 -LIPOXYGENASE ACTIVATING PROTEIN ( FLAP) | MERCK & CO., INC. (US) | 2008-03-13 | — | — | WO | claimed |