Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | PMM2 | O15305 | 1/20 | 0.46 |
| ▸ | MPI | P34949 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CTSG | P08311 | 1/20 | 0.45 |
| ▸ | CMA1 | P23946 | 1/20 | 0.45 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219621 | 0.86 | GAA (0.54) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL5219880 | 0.85 | GAA (0.53) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL2623592 | 0.82 | GAA (0.55) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL2623576 | 0.82 | GAA (0.55) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL4125490 | 0.80 | NOTUM (0.43) | GAAGRM2ALDH1A1LMNAHPGD | |
| SCHEMBL5226071 | 0.78 | GAA (0.51) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL6568249 | 0.77 | GAA (0.56) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL14898094 | 0.77 | GAA (0.53) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL14879792 | 0.77 | GAA (0.53) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL14898279 | 0.77 | GAA (0.53) | GAAGRM2ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090253671-A1 | TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2009-10-08 | — | — | US | disclosed |
| EP-1861396-A1 | TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY | AstraZeneca AB (SE) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006092608-A1 | TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY | ASTRAZENECA AB (SE) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253671-A1 | TRICYCLIC DERIVATIVES OF AZETIDINE AND PYRROLE WITH ANTIBACTERIAL ACTIVITY | AZI2, AAAS, QDPR | GAA 219/4885GRM2 4726/4885ALDH1A1 2333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.