Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | PMM2 | O15305 | 1/20 | 0.41 |
| ▸ | MPI | P34949 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219340 | 0.89 | GAA (0.49) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL5219621 | 0.82 | GAA (0.54) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL5223388 | 0.78 | GRM2 (0.51) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL2623576 | 0.78 | GAA (0.55) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL2623592 | 0.78 | GAA (0.55) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL4121023 | 0.78 | GAA (0.57) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL5219880 | 0.74 | GAA (0.53) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL29040801 | 0.73 | GAA (0.46) | GAAGRM2ALDH1A1TP53HPGD | |
| SCHEMBL6568249 | 0.72 | GAA (0.56) | GAAGRM2ALDH1A1LMNAMAPK1 | |
| SCHEMBL14879916 | 0.71 | ALDH1A1 (0.53) | GAAGRM2ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567488-B1 | HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE | GLAXO GROUP LTD (GB) | 2007-02-21 | — | — | EP | disclosed |