Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNMT1 | P26358 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19230419 | 0.77 | DNMT1 (0.83) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL16144677 | 0.75 | DNMT1 (0.80) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3327381 | 0.74 | DNMT1 (0.50) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3331813 | 0.74 | DNMT1 (0.50) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5940303 | 0.74 | MEN1 (0.54) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7122517 | 0.71 | DNMT1 (0.73) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2175783 | 0.70 | DNMT1 (0.92) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1055754 | 0.70 | DNMT1 (1.00) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL31174009 | 0.70 | DNMT1 (1.00) | DNMT1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL29440308 | 0.70 | DNMT1 (0.92) | DNMT1ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150335610-A1 | PDK4 INHIBITOR AND USE THEREOF | THE UNIVERSITY OF TOKUSHIMA (JP) | 2015-11-26 | — | — | US | disclosed |
| US-8513227-B2 | Inhibition of inflammatory cytokine production with tanshinones | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2013-08-20 | — | — | US | disclosed |
| EP-1981489-B1 | INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION WITH TANSHINONES | THE FEINSTEIN INST MEDICAL RES (US) | 2013-05-01 | — | — | EP | disclosed |
| US-20090221542-A1 | Inhibition of Inflammatory Cytokine Production With Tanshinones | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2009-09-03 | — | — | US | disclosed |
| EP-1981489-A2 | INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION WITH TANSHINONES | The Feinstein Institute for Medical Research (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007084419-A2 | INHIBITION OF INFLAMMATORY CYTOKINE PRODUCTION WITH TANSHINONES | THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) | 2007-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150335610-A1 | PDK4 INHIBITOR AND USE THEREOF | PDK4, PDK3, PDK2 | DNMT1 4795/4885ALDH1A1 152/4885MEN1 3635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.