Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4286812 | 0.89 | MAPT (0.46) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL18188610 | 0.72 | ROCK2 (0.45) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL2846013 | 0.71 | BACE1 (0.42) | KMT2ACYP2D6MAOBPOLB | |
| SCHEMBL4121858 | 0.70 | ROCK2 (0.46) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL4292713 | 0.70 | TAAR1 (0.35) | KDM4EALDH1A1HPGDRAB9ATDP1 | |
| SCHEMBL31158403 | 0.66 | SLC6A2 (0.53) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL26633622 | 0.66 | SLC6A2 (0.53) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL117208 | 0.65 | ROCK2 (1.00) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL29372553 | 0.65 | ROCK2 (1.00) | ROCK2MAPTKDM4EMEN1KMT2A | |
| SCHEMBL17033105 | 0.64 | ROCK2 (0.49) | ROCK2MAPTKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009063240-A1 | 2,4-DIAMINOPYRIMIDINE DERIVATIVES USEFUL AS INHIBITORS OF AURORA KINASE | ARROW THERAPEUTICS LIMITED (GB) | 2009-05-22 | — | — | WO | disclosed |