Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 4/20 | 0.43 |
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4121853 | 0.89 | ROCK2 (0.46) | MAPTKDM4EMEN1KMT2APKM | |
| SCHEMBL4292713 | 0.73 | TAAR1 (0.35) | KDM4EALDH1A1TDP1HPGDRAB9A | |
| SCHEMBL1171624 | 0.71 | MAPT (0.47) | MAPTKDM4EMEN1KMT2APKM | |
| SCHEMBL2846013 | 0.71 | BACE1 (0.42) | KMT2ALMNACYP2D6CYP2C9BLM | |
| SCHEMBL4277498 | 0.70 | MAPT (0.46) | MAPTKDM4EMEN1KMT2APKM | |
| SCHEMBL29559746 | 0.65 | MAPT (1.00) | MAPTKDM4EMEN1KMT2APKM | |
| SCHEMBL177260 | 0.65 | MAPT (1.00) | MAPTKDM4EMEN1KMT2APKM | |
| Bromide SCHEMBL2933643 | 0.64 | MAPT (0.96) | MAPTKDM4EMEN1KMT2APKM | |
| Hydrochloric Acid SCHEMBL2925515 | 0.64 | MAPT (0.96) | MAPTKDM4EMEN1KMT2APKM | |
| Hydrochloric Acid SCHEMBL3871258 | 0.64 | MAPT (0.96) | MAPTKDM4EMEN1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | claimed |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | CELL THERAPEUTICS, INC. (US) | 2009-04-16 | — | — | US | disclosed |
| US-7419984-B2 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. (US) | 2008-09-02 | — | — | US | disclosed |
| US-20040204386-A1 | Pyrimidines and uses thereof | CELL THERAPEUTICS, INC. | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204386-A1 | Pyrimidines and uses thereof | LPCAT3, LPCAT1, APRT | MAPT 3800/4885KDM4E 1842/4885MEN1 3158/4885 |
| US-20090099183-A1 | PYRIMIDINES AND USES THEREOF | LPCAT3, LPCAT1, APRT | MAPT 3707/4885KDM4E 2160/4885MEN1 3425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.